PXD022719

PXD022719 is an original dataset announced via ProteomeXchange.

Title	The tricuspid valve also maladapts as shown in sheep with biventricular heart failure
Description	Over 1.6 million Americans suffer from significant tricuspid valve leakage. In most cases this leakage is designated as secondary. Thus, valve dysfunction is assumed to be due to valve extrinsic factors. We challenge this paradigm and hypothesize that the tricuspid valve maladapts in those patients rendering the valve at least partially culpable for its dysfunction. As a first step in testing this hypothesis, we set out to demonstrate that the tricuspid valve maladapts in disease. To this end, we induced biventricular heart failure in sheep that developed tricuspid valve leakage. In the anterior leaflets of those animals, we investigated maladaptation on multiple scales. We demonstrated alterations on the protein and cell-level, leading to tissue growth, thickening, and stiffening. These data provide a new perspective on a poorly understood, yet highly prevalent disease. Our findings may motivate novel therapy option for many currently untreated patients with leaky tricuspid valves.
HostingRepository	PRIDE
AnnounceDate	2021-09-09
AnnouncementXML	Submission_2021-09-09_14:43:54.823.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Carla Lacerda
SpeciesList	scientific name: Ovis aries; NCBI TaxID: 9940;
ModificationList	iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2020-11-25 03:09:03	ID requested
⏵ 1	2021-09-09 14:43:55	announced

Meador WD, Mathur M, Sugerman GP, Malinowski M, Jazwiec T, Wang X, Lacerda CM, Timek TA, Rausch MK, The tricuspid valve also maladapts as shown in sheep with biventricular heart failure. Elife, 9():(2020) [pubmed]

submitter keyword: LC-MS/MS, tricuspid valve

Manuel Rausch
contact affiliation	University of Texas Austin
contact email	manuel.rausch@utexas.edu
lab head
Carla Lacerda
contact affiliation	Texas Tech University
contact email	carla.lacerda@ttu.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD022719
     1. Label: PRIDE project
     2. Name: The tricuspid valve also maladapts as shown in sheep with biventricular heart failure