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PXD022719

PXD022719 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleThe tricuspid valve also maladapts as shown in sheep with biventricular heart failure
DescriptionOver 1.6 million Americans suffer from significant tricuspid valve leakage. In most cases this leakage is designated as secondary. Thus, valve dysfunction is assumed to be due to valve extrinsic factors. We challenge this paradigm and hypothesize that the tricuspid valve maladapts in those patients rendering the valve at least partially culpable for its dysfunction. As a first step in testing this hypothesis, we set out to demonstrate that the tricuspid valve maladapts in disease. To this end, we induced biventricular heart failure in sheep that developed tricuspid valve leakage. In the anterior leaflets of those animals, we investigated maladaptation on multiple scales. We demonstrated alterations on the protein and cell-level, leading to tissue growth, thickening, and stiffening. These data provide a new perspective on a poorly understood, yet highly prevalent disease. Our findings may motivate novel therapy option for many currently untreated patients with leaky tricuspid valves.
HostingRepositoryPRIDE
AnnounceDate2021-09-09
AnnouncementXMLSubmission_2021-09-09_14:43:54.823.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterCarla Lacerda
SpeciesList scientific name: Ovis aries; NCBI TaxID: 9940;
ModificationListiodoacetamide derivatized residue
InstrumentLTQ Orbitrap Elite
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-11-25 03:09:03ID requested
12021-09-09 14:43:55announced
Publication List
Meador WD, Mathur M, Sugerman GP, Malinowski M, Jazwiec T, Wang X, Lacerda CM, Timek TA, Rausch MK, The tricuspid valve also maladapts as shown in sheep with biventricular heart failure. Elife, 9():(2020) [pubmed]
Keyword List
submitter keyword: LC-MS/MS, tricuspid valve
Contact List
Manuel Rausch
contact affiliationUniversity of Texas Austin
contact emailmanuel.rausch@utexas.edu
lab head
Carla Lacerda
contact affiliationTexas Tech University
contact emailcarla.lacerda@ttu.edu
dataset submitter
Full Dataset Link List
Dataset FTP location
PRIDE project URI
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