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PXD022714

PXD022714 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleAge-Associated Proteomic Hallmarks and Potential Clinically Actionable Targets of Colorectal Cancer
DescriptionColorectal cancer (CRC) is the third most frequent cancer usually occurring in elderly persons. However, the molecular characteristics of old-onset CRC remain largely unknown. Here we performed proteomic profiling from 52 CRC tumors and their paired non-cancerous adjacent tissues and delineated the distinct molecular attributes and hallmarks of tumor progression in old-onset CRC patients over 60 years old. Then we screened out candidate proteins highly correlated with age in CRC patients through logistic regression algorithm. Besides comparative proteomic analysis of tumors and NATs revealed a catalog of age-associated proteins, including drug targets, oncogenes, transcription factors and tumor suppressors. Immunohistochemical analysis showed that the CRC patients with high NHP2 expression had lower overall survival rate and the older persons had the worse the prognosis. Cell viability and clone formation experiments revealed that knockdown of NHP2 in HT29 and SW620 cell lines inhibited cell proliferation. Collectively, this study provides a deeper understanding of cancer biology leading to old-onset CRC, and identifies potential biomarkers and therapeutic targets for old-onset CRC patients.
HostingRepositoryiProX
AnnounceDate2021-04-16
AnnouncementXMLSubmission_2023-03-02_18:26:40.488.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterYanqiu Gong
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive Plus
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-11-24 20:55:42ID requested
12021-04-15 20:29:32announced
22023-03-02 18:26:41announced2023-03-03: Update publication information.
Publication List
Gong Y, Liu Y, Wang T, Li Z, Gao L, Chen H, Shu Y, Li Y, Xu H, Zhou Z, Dai L, Age-Associated Proteomic Signatures and Potential Clinically Actionable Targets of Colorectal Cancer. Mol Cell Proteomics, 20():100115(2021) [pubmed]
Keyword List
submitter keyword: Colorectal cancer, old-onset, NHP2
Contact List
Lunzhi Dai
contact affiliationSichuan University
contact emaillunzhi.dai@scu.edu.cn
lab head
Yanqiu Gong
contact affiliationSichuan University
contact emailniqiu.er@163.com
dataset submitter
Full Dataset Link List
iProX dataset URI