PXD022714

PXD022714 is an original dataset announced via ProteomeXchange.

Title	Age-Associated Proteomic Hallmarks and Potential Clinically Actionable Targets of Colorectal Cancer
Description	Colorectal cancer (CRC) is the third most frequent cancer usually occurring in elderly persons. However, the molecular characteristics of old-onset CRC remain largely unknown. Here we performed proteomic profiling from 52 CRC tumors and their paired non-cancerous adjacent tissues and delineated the distinct molecular attributes and hallmarks of tumor progression in old-onset CRC patients over 60 years old. Then we screened out candidate proteins highly correlated with age in CRC patients through logistic regression algorithm. Besides comparative proteomic analysis of tumors and NATs revealed a catalog of age-associated proteins, including drug targets, oncogenes, transcription factors and tumor suppressors. Immunohistochemical analysis showed that the CRC patients with high NHP2 expression had lower overall survival rate and the older persons had the worse the prognosis. Cell viability and clone formation experiments revealed that knockdown of NHP2 in HT29 and SW620 cell lines inhibited cell proliferation. Collectively, this study provides a deeper understanding of cancer biology leading to old-onset CRC, and identifies potential biomarkers and therapeutic targets for old-onset CRC patients.
HostingRepository	iProX
AnnounceDate	2021-04-16
AnnouncementXML	Submission_2023-03-02_18:26:40.488.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yanqiu Gong
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2020-11-24 20:55:42	ID requested
1	2021-04-15 20:29:32	announced
⏵ 2	2023-03-02 18:26:41	announced	2023-03-03: Update publication information.

Gong Y, Liu Y, Wang T, Li Z, Gao L, Chen H, Shu Y, Li Y, Xu H, Zhou Z, Dai L, Age-Associated Proteomic Signatures and Potential Clinically Actionable Targets of Colorectal Cancer. Mol Cell Proteomics, 20():100115(2021) [pubmed]

submitter keyword: Colorectal cancer, old-onset, NHP2

Lunzhi Dai
contact affiliation	Sichuan University
contact email	lunzhi.dai@scu.edu.cn
lab head
Yanqiu Gong
contact affiliation	Sichuan University
contact email	niqiu.er@163.com
dataset submitter

iProX dataset URI