PXD022714
PXD022714 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Age-Associated Proteomic Hallmarks and Potential Clinically Actionable Targets of Colorectal Cancer |
Description | Colorectal cancer (CRC) is the third most frequent cancer usually occurring in elderly persons. However, the molecular characteristics of old-onset CRC remain largely unknown. Here we performed proteomic profiling from 52 CRC tumors and their paired non-cancerous adjacent tissues and delineated the distinct molecular attributes and hallmarks of tumor progression in old-onset CRC patients over 60 years old. Then we screened out candidate proteins highly correlated with age in CRC patients through logistic regression algorithm. Besides comparative proteomic analysis of tumors and NATs revealed a catalog of age-associated proteins, including drug targets, oncogenes, transcription factors and tumor suppressors. Immunohistochemical analysis showed that the CRC patients with high NHP2 expression had lower overall survival rate and the older persons had the worse the prognosis. Cell viability and clone formation experiments revealed that knockdown of NHP2 in HT29 and SW620 cell lines inhibited cell proliferation. Collectively, this study provides a deeper understanding of cancer biology leading to old-onset CRC, and identifies potential biomarkers and therapeutic targets for old-onset CRC patients. |
HostingRepository | iProX |
AnnounceDate | 2021-04-16 |
AnnouncementXML | Submission_2023-03-02_18:26:40.488.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Yanqiu Gong |
SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive Plus |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2020-11-24 20:55:42 | ID requested | |
1 | 2021-04-15 20:29:32 | announced | |
⏵ 2 | 2023-03-02 18:26:41 | announced | 2023-03-03: Update publication information. |
Publication List
Gong Y, Liu Y, Wang T, Li Z, Gao L, Chen H, Shu Y, Li Y, Xu H, Zhou Z, Dai L, Age-Associated Proteomic Signatures and Potential Clinically Actionable Targets of Colorectal Cancer. Mol Cell Proteomics, 20():100115(2021) [pubmed] |
Keyword List
submitter keyword: Colorectal cancer, old-onset, NHP2 |
Contact List
Lunzhi Dai | |
---|---|
contact affiliation | Sichuan University |
contact email | lunzhi.dai@scu.edu.cn |
lab head | |
Yanqiu Gong | |
contact affiliation | Sichuan University |
contact email | niqiu.er@163.com |
dataset submitter |
Full Dataset Link List
iProX dataset URI |