PXD022678

PXD022678 is an original dataset announced via ProteomeXchange.

Title	The landscape of molecular chaperones across human tissues reveals a layered architecture of core-variable chaperones
Description	The sensitivity of the protein-folding environment to chaperone disruption can be highly tissue-specific. Yet, the organization of the chaperone system across physiological human tissues has received little attention. Through computational analyses of large-scale tissue transcriptomes, we unveiled that the chaperone system is composed of core elements that are uniformly expressed across tissues, and variable elements that are differentially expressed to fit with tissue-specific requirements. We demonstrate via a proteomic analysis of a mouse myoblast cell line that the muscle-specific signature is functional and conserved. Core chaperones were significantly more abundant across tissues and more important for cell survival than variable chaperones. Together with variable chaperones, they formed tissue-specific functional networks. Analysis of human organ development and aging brain transcriptomes revealed that these functional networks were maintained in development and declined with age. Our findings expand the known functional organization of de novo versus stress-inducible eukaryotic chaperones into a layered core-variable architecture in multi-cellular organisms.
HostingRepository	PRIDE
AnnounceDate	2021-02-08
AnnouncementXML	Submission_2021-04-22_22:42:01.922.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Keren Bendalak
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monoacetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2020-11-23 09:32:23	ID requested
1	2021-02-07 23:21:52	announced
⏵ 2	2021-04-22 22:42:03	announced	2021-04-23: Updated publication reference for PubMed record(s): 33846299.

Shemesh N, Jubran J, Dror S, Simonovsky E, Basha O, Argov C, Hekselman I, Abu-Qarn M, Vinogradov E, Mauer O, Tiago T, Carra S, Ben-Zvi A, Yeger-Lotem E, The landscape of molecular chaperones across human tissues reveals a layered architecture of core and variable chaperones. Nat Commun, 12(1):2180(2021) [pubmed]

submitter keyword: Chaperones

Aging

Data integration

Differentiation

Protein quality control

Protein misfolding diseases

Proteostasis

Systems biology

Tissue specificity compression networks

Anat Ben-Zvi
contact affiliation	Ben-Gurion University
contact email	anatbz@bgu.ac.il
lab head
Keren Bendalak
contact affiliation	Technion
contact email	kerenb@technion.ac.il
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/02/PXD022678

PRIDE project URI

• PRIDE
  1. PXD022678
     1. Label: PRIDE project
     2. Name: The landscape of molecular chaperones across human tissues reveals a layered architecture of core-variable chaperones