PXD022672

PXD022672 is an original dataset announced via ProteomeXchange.

Title	Metabolic reprogramming and host-immune response against Crimean-Congo Hemorrhagic Fever Viruses (CCHFV) during acute infection
Description	The pathogenesis and host viral interactions of the Crimean–Congo hemorrhagic fever virus (CCHFV) are convoluted and have not been evaluated previously. To understand the host immune responses against CCHFV, we have performed a global transcriptomic analysis of peripheral blood mononuclear cells from a longitudinal cohort of CCHF patients who survived, and a temporal untargeted proteomics analysis of CCHFV infected cells. Our results indicate that during the acute phase of CCHFV infection, metabolic reprogramming of the host towards central carbon metabolism including glycolysis/gluconeogenesis occurs. This could potentially be regulated by the PI3K/Akt, HIF-1, FoxO, and AMPK signaling pathways and play a central role in viral replication. Moreover, key interferon stimulating genes (ISGs: ISG12, ISG15, ISG20 and MXs: Mx1 and Mx2) are activated during infection, suggesting a role for type I and II interferon-mediated antiviral mechanisms. Targeting type I interferon response through metabolic rewiring could be an attractive therapeutic intervention for CCHFV.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:51:18.333.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	JIMMY RODRIGUEZ
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2020-11-23 09:31:55	ID requested
1	2022-05-04 05:02:55	announced
⏵ 2	2023-11-14 08:51:18	announced	2023-11-14: Updated project metadata.

Dataset with its publication pending

submitter keyword: CCHFV, cell lines, transcriptomics, LC-MS/MS

Ákos Végvári
contact affiliation	Division of Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
contact email	akos.vegvari@ki.se
lab head
JIMMY RODRIGUEZ
contact affiliation	Division of Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
contact email	esneider007@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/05/PXD022672

PRIDE project URI

• PRIDE
  1. PXD022672
     1. Label: PRIDE project
     2. Name: Metabolic reprogramming and host-immune response against Crimean-Congo Hemorrhagic Fever Viruses (CCHFV) during acute infection