PXD022644 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | First penicillin-binding protein occupancy patterns for 15 β-lactams and β-lactamase inhibitors in Mycobacterium abscessus |
Description | Mycobacterium abscessus (Mab) causes serious infections that often require over 18 months of antibiotic combination therapy. With β lactam antibiotics being safe, double β-lactam and β-lactam/β-lactamase inhibitor combinations are of interest for improving treatment of Mab infections and minimizing toxicity. However, a mechanistic approach for building these combinations is lacking since little is known about which penicillin-binding protein (PBP) target receptors are inactivated by different β-lactams in Mab. This project aimed to identify PBPs in Mab and study the binding affinities of each of these PBPs with β-lactam antibiotics. These first PBP occupancy patterns in Mab provide a mechanistic foundation for selecting and optimizing safe and effective combination therapies with β-lactams. |
HostingRepository | PRIDE |
AnnounceDate | 2020-12-01 |
AnnouncementXML | Submission_2020-11-30_23:09:00.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD022644 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Yinzhi Lang |
SpeciesList | scientific name: Mycobacteroides abscessus ATCC 19977; NCBI TaxID: 561007; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue; deamidated residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-11-20 02:58:08 | ID requested | |
1 | 2020-11-23 23:29:29 | announced | |
⏵ 2 | 2020-11-30 23:09:01 | announced | 2020-12-01: Updated project metadata. |
Publication List
Sayed ARM, Shah NR, Basso KB, Kamat M, Jiao Y, Moya B, Sutaria DS, Lang Y, Tao X, Liu W, Shin E, Zhou J, Werkman C, Louie A, Drusano GL, Bulitta JB, -Lactamase Inhibitors in Mycobacterium abscessus. Antimicrob Agents Chemother, 65(1):(2020) [pubmed] |
Sutaria DS, Moya B, Green KB, Kim TH, Tao X, Jiao Y, Louie A, Drusano GL, Bulitta JB, -Lactamase Inhibitors in Klebsiella pneumoniae. Antimicrob Agents Chemother, 62(6):(2018) [pubmed] |
Keyword List
submitter keyword: Penicillin-binding proteins, Mycobacterium abscessus, beta-lactams, cell wall biosynthesis, PonA2, PonA1, PbpA |
Contact List
Jürgen B. Bulitta |
contact affiliation | Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Orlando, FL |
contact email | jbulitta@cop.ufl.edu |
lab head | |
Yinzhi Lang |
contact affiliation | Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida |
contact email | y.lang@ufl.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD022644
- Label: PRIDE project
- Name: First penicillin-binding protein occupancy patterns for 15 β-lactams and β-lactamase inhibitors in Mycobacterium abscessus