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PXD022644

PXD022644 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleFirst penicillin-binding protein occupancy patterns for 15 β-lactams and β-lactamase inhibitors in Mycobacterium abscessus
DescriptionMycobacterium abscessus (Mab) causes serious infections that often require over 18 months of antibiotic combination therapy. With β lactam antibiotics being safe, double β-lactam and β-lactam/β-lactamase inhibitor combinations are of interest for improving treatment of Mab infections and minimizing toxicity. However, a mechanistic approach for building these combinations is lacking since little is known about which penicillin-binding protein (PBP) target receptors are inactivated by different β-lactams in Mab. This project aimed to identify PBPs in Mab and study the binding affinities of each of these PBPs with β-lactam antibiotics. These first PBP occupancy patterns in Mab provide a mechanistic foundation for selecting and optimizing safe and effective combination therapies with β-lactams.
HostingRepositoryPRIDE
AnnounceDate2020-12-01
AnnouncementXMLSubmission_2020-11-30_23:09:00.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD022644
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterYinzhi Lang
SpeciesList scientific name: Mycobacteroides abscessus ATCC 19977; NCBI TaxID: 561007;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue; deamidated residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-11-20 02:58:08ID requested
12020-11-23 23:29:29announced
22020-11-30 23:09:01announced2020-12-01: Updated project metadata.
Publication List
Sayed ARM, Shah NR, Basso KB, Kamat M, Jiao Y, Moya B, Sutaria DS, Lang Y, Tao X, Liu W, Shin E, Zhou J, Werkman C, Louie A, Drusano GL, Bulitta JB, -Lactamase Inhibitors in Mycobacterium abscessus. Antimicrob Agents Chemother, 65(1):(2020) [pubmed]
Sutaria DS, Moya B, Green KB, Kim TH, Tao X, Jiao Y, Louie A, Drusano GL, Bulitta JB, -Lactamase Inhibitors in Klebsiella pneumoniae. Antimicrob Agents Chemother, 62(6):(2018) [pubmed]
Keyword List
submitter keyword: Penicillin-binding proteins, Mycobacterium abscessus, beta-lactams, cell wall biosynthesis, PonA2, PonA1, PbpA
Contact List
Jürgen B. Bulitta
contact affiliationDepartment of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Orlando, FL
contact emailjbulitta@cop.ufl.edu
lab head
Yinzhi Lang
contact affiliationDepartment of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida
contact emaily.lang@ufl.edu
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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