PXD022613

PXD022613 is an original dataset announced via ProteomeXchange.

Title	Characterization of biomarkers in Colorectal Cancer Liver Metastases as a prognostic tool
Description	In this study we aimed to explore the molecular landscape of hepatic metastases and adjacent tissue in order to delineate a potential molecular signature that may be predictive for clinical benefit of CRCLM resection. Consecutive patients who underwent CRCLM resection between 2008 and 2015 at RMC, and for whom pathological specimen was available were included in the study. Cases were divided into two cohorts based on the interval between resection of liver metastases and disease recurrence- patients with less than 12-month interval were defined as ×´poor prognosis×´ (PP) and patients with more than 12 months as ×´good prognosis×´ (GP). Clinical data was retrieved from the medical records. Proteomic analysis was performed on the pathological bio specimen and correlated to demographics and clinical outcomes. Fifty-eight patients were included in the study. 29 in the GP cohort and 29 in the PP cohort. Proteomic analysis of the two-cohort revealed 99 proteins that were 38 differentially expressed, about a third of them associate with the extracellular matrix (ECM) pathways as the matrix metalloproteinases (MMPs).
HostingRepository	PRIDE
AnnounceDate	2022-02-16
AnnouncementXML	Submission_2022-02-16_10:25:25.702.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Tamar Ziv
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2020-11-19 03:31:01	ID requested
⏵ 1	2022-02-16 10:25:26	announced

Michal S, Tal GL, Gali P, Miki G, Elana B, Baroch B, Hanoch K, Irit BA, Riad H, Characterization of Biomarkers in Colorectal Cancer Liver Metastases as a Prognostic Tool. J Pers Med, 11(11):(2021) [pubmed]

submitter keyword: Colorectal Cancer Liver Metastasis, Hepatic Surgery, Prognosis, Biomarkers, Molecular Signature.

Irit Ben-Aharon
contact affiliation	Division of Oncology, Rambam Health Care Campus & Rappaport Faculty of Medicine, Technion, Haifa, Israel
contact email	I_benaharon@rambam.health.gov.il
lab head
Tamar Ziv
contact affiliation	Technion
contact email	tamarz@technion.ac.il
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD022613

PRIDE project URI

• PRIDE
  1. PXD022613
     1. Label: PRIDE project
     2. Name: Characterization of biomarkers in Colorectal Cancer Liver Metastases as a prognostic tool