PXD022600

PXD022600 is an original dataset announced via ProteomeXchange.

Title	Constitutive Protein Kinase G Activation Exacerbates Stress-induced Cardiomyopathy
Description	: Heart failure is associated with high morbidity and mortality, and new therapeutic targets are needed. Preclinical data suggest that pharmacological activation of protein kinase G (PKG) can reduce maladaptive ventricular remodeling and cardiac dysfunction in the stressed heart. However, clinical trial results have been mixed, and the effects of long-term PKG activation in the heart are unknown.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_09:02:23.483.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Majid Ghassemian
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	phosphorylated residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2020-11-18 01:40:56	ID requested
1	2023-07-20 10:36:10	announced
⏵ 2	2023-11-14 09:02:24	announced	2023-11-14: Updated project metadata.

Schwaerzer GK, Casteel DE, Cividini F, Kalyanaraman H, Zhuang S, Gu Y, Dalton ND, Peterson KL, Dillmann WH, Boss GR, Pilz RB, Constitutive protein kinase G activation exacerbates stress-induced cardiomyopathy. Br J Pharmacol, 179(11):2413-2429(2022) [pubmed]

ProteomeXchange project tag: Cardiovascular (B/D-HPP), Biology/Disease-Driven Human Proteome Project (B/D-HPP), Human Proteome Project

submitter keyword: LC-MSMS,Protein Kinase G

Renate B. Pilz
contact affiliation	Department of Medicine, University of California San Diego, La Jolla, California 92093
contact email	rpilz@ucsd.edu
lab head
Majid Ghassemian
contact affiliation	Scientist
contact email	mghassem@ucsd.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD022600

PRIDE project URI

• PRIDE
  1. PXD022600
     1. Label: PRIDE project
     2. Name: Constitutive Protein Kinase G Activation Exacerbates Stress-induced Cardiomyopathy