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PXD022558

PXD022558 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleQuantitative proteomic TandemMassTag analysis of intestinal epithelial cells (IEC) deleted for both Hdac1 and Hdac2
DescriptionWe have performed quantitative proteomic TandemMassTag to investigate proteomic changes after deletion of epigenetic eraser genes Hdac1 and Hdac2 in intestinal epithelial cells. Both HDAC1 and HDAC2 are epigenetic erasers that drive specific and redundant gene expression patterns, in part by removing acetyl groups on histones. Deletion of these Hdac in intestinal epithelial cell (IEC) in vivo alters intestinal homeostasis, dependent on the Hdac deleted and the level of expression of both. To determine the specific IEC function of HDAC1 and HDAC2, we have performed transcriptomic and quantitative proteomic approaches on IEC deficient in Hdac1 and Hdac2. We have defined changes in both mRNA and protein expression patterns affecting IEC differentiation. We have identified IEC Hdac1- and Hdac2-dependent common as well as specific pathways and biological processes. These findings uncover unrecognized similarities and differences between Hdac1 and Hdac2 in IEC.
HostingRepositoryPRIDE
AnnounceDate2021-09-09
AnnouncementXMLSubmission_2021-09-09_13:19:58.309.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterDominique Levesque
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListacetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-11-16 03:39:51ID requested
12021-09-09 13:19:59announced
Publication List
Gonneaud A, Turgeon N, Boisvert FM, Boudreau F, Asselin C, -Intestinal Epithelial Cell-Deficient Mice. Cells, 10(2):(2021) [pubmed]
Keyword List
submitter keyword: Intestinal epithelial cell, HDAC, proteome
Contact List
Claude Asselin
contact affiliationClaude Asselin, Université de Sherbrooke, Department of immunology and Cell Biology, Faculty of medicine and Health Sciences, Université de Sherbrooke (lab head)
contact emailclaude.asselin@USherbrooke.ca
lab head
Dominique Levesque
contact affiliationUniversity of Sherbrooke, FM Boisvert lab
contact emaildominique.levesque@usherbrooke.ca
dataset submitter
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Dataset FTP location
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