PXD022551

PXD022551 is an original dataset announced via ProteomeXchange.

Title	Virulence of Vibrio alginolyticus as determinants of immune outcomes in the oyster Crassostrea hongkongensis
Description	Vibrio species distribute ubiquitously in marine and coastal environments, with implications for severe infectious diseases in human and marine animals. However, precisely what defensive strategies the host employ against Vibrio pathogens with distinct virulence remain poorly understood. Being an ecologically relevant host, the oyster Crassostrea hongkongensis serves as an excellent model for elucidating mechanisms underlying host-Vibrio interactions. In this study, we generated one mutant Vibrio alginolyticus strains (V. alginolyticus△VSCC) with attenuated virulence by knocking out the VSCC encoding gene, one of the core components of type III secretion systems (T3SSs), based on the evidence that V. alginolyticus△VSCC infection leads to a marked reduction in the apoptotic rate of hemocyte hosts, compared to V. alginolyticusWT control. In comparative proteomics, it was revealed that distinct immune responses were elicited upon encounter with V. alginolyticus strains of different virulence. Quite strikingly, the peroxisomal and apoptotic pathways are activated by V. alginolyticusWT infection, whereas phagocytosis and cell adhesion were enhanced in V. alginolyticus△VSCC infection. Collectively, we conclude that adaptation in host immune responses is determined in part by pathogen virulence, which safeguards elimination of invading bacteria in efficient and timely manners.
HostingRepository	PRIDE
AnnounceDate	2022-02-16
AnnouncementXML	Submission_2022-02-16_09:48:46.960.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Liu Kunna
SpeciesList	scientific name: Crassostrea hongkongensis; NCBI TaxID: 298176;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2020-11-16 03:39:14	ID requested
⏵ 1	2022-02-16 09:48:49	announced

Mao F, Liu K, Wong NK, Zhang X, Yi W, Xiang Z, Xiao S, Yu Z, Zhang Y, . Front Immunol, 12():746017(2021) [pubmed]

submitter keyword: Vibrio alginolyticus, oyster, virulence, host-pathogen interactions, proteomics

Yang Zhang
contact affiliation	CAS Key Laboratory of Tropical Marine Bio-resources and Ecology and Guangdong Provincial Key Laboratory of Applied Marine Biology, South China Sea Institute of Oceanology, Chinese Academy of Science. Guangzhou, China
contact email	yzhang@scsio.ac.cn
lab head
Liu Kunna
contact affiliation	South China sea institude of Chinese academy of science
contact email	18811361078@163.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD022551

PRIDE project URI

• PRIDE
  1. PXD022551
     1. Label: PRIDE project
     2. Name: Virulence of Vibrio alginolyticus as determinants of immune outcomes in the oyster Crassostrea hongkongensis