PXD022545

PXD022545 is an original dataset announced via ProteomeXchange.

Title	Proteomic analysis of ARPE-19 cells exposed to chronic H2O2 treatment
Description	We performed a proteomic analysis of a retinal pigment epithelium cell line (ARPE-19) exposed to long-term sublethal levels of H2O2 to mimic low-level pro-oxidative insult in age-related macular degeneration (AMD). using a wide range of biochemical analyses and cell culture techniques, we highlighted changes in energy metabolism, extracellular matrix organization and inflammation-related processes, which may help in understanding the molecular pathogenesis of AMD.
HostingRepository	PRIDE
AnnounceDate	2021-03-04
AnnouncementXML	Submission_2021-03-04_14:51:02.415.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Davide Chiasserini
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2020-11-16 03:38:43	ID requested
⏵ 1	2021-03-04 14:51:03	announced

Macchioni L, Chiasserini D, Mezzasoma L, Davidescu M, Orvietani PL, Fettucciari K, Salviati L, Cellini B, Bellezza I, Crosstalk between Long-Term Sublethal Oxidative Stress and Detrimental Inflammation as Potential Drivers for Age-Related Retinal Degeneration. Antioxidants (Basel), 10(1):(2020) [pubmed]

submitter keyword: ARPE-19, retinal pigment epithelium, oxidative stress, macular degeneration

Davide Chiasserini
contact affiliation	Department of Medicine, section of Physiology and Biochemistry, University of Perugia
contact email	davide.chiasserini@unipg.it
lab head
Davide Chiasserini
contact affiliation	Department of Experimental Medicine, Section of Physiology and Biochemistry
contact email	davide.chiasserini@unipg.it
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/01/PXD022545

PRIDE project URI

• PRIDE
  1. PXD022545
     1. Label: PRIDE project
     2. Name: Proteomic analysis of ARPE-19 cells exposed to chronic H2O2 treatment