PXD022542

PXD022542 is an original dataset announced via ProteomeXchange.

Title	Identification of chromatin-associated proteins occupying the promoter region of CDKN1A
Description	The p21 protein, encoded by CDKN1A, plays a vital role in the induction of senescence, and its transcriptional control by p53 tumour supressor is well-established. However, p21 can also be regulated in a p53-independent manner, by mechanisms that remain poorly understood. Therefore, we here used a chromatin-directed proteomic approach and identified ZNF84 as a novel regulator of p21 in various p53-deficient cell lines.
HostingRepository	PRIDE
AnnounceDate	2021-09-07
AnnouncementXML	Submission_2021-09-07_03:22:22.989.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Mahmoudreza Rafiee
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2020-11-16 03:38:26	ID requested
⏵ 1	2021-09-07 03:22:23	announced

Strzeszewska-Potyra, ł, a A, Staniak K, Czarnecka-Herok J, Rafiee MR, Herok M, Mosieniak G, Krijgsveld J, Sikora E, Chromatin-Directed Proteomics Identifies ZNF84 as a p53-Independent Regulator of p21 in Genotoxic Stress Response. Cancers (Basel), 13(9):(2021) [pubmed]

submitter keyword: CDKN1A, Chromatin-associated proteins, ZNF84

Jeroen Krijgsveld
contact affiliation	German Cancer Research Center (DKFZ), Heidelberg, Germany Medical Faculty, Heidelberg University, Heidelberg, Germany
contact email	j.krijgsveld@dkfz-heidelberg.de
lab head
Mahmoudreza Rafiee
contact affiliation	The Francis Crick Institute
contact email	rafieem@crick.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/09/PXD022542

PRIDE project URI

• PRIDE
  1. PXD022542
     1. Label: PRIDE project
     2. Name: Identification of chromatin-associated proteins occupying the promoter region of CDKN1A