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PXD022542

PXD022542 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleIdentification of chromatin-associated proteins occupying the promoter region of CDKN1A
DescriptionThe p21 protein, encoded by CDKN1A, plays a vital role in the induction of senescence, and its transcriptional control by p53 tumour supressor is well-established. However, p21 can also be regulated in a p53-independent manner, by mechanisms that remain poorly understood. Therefore, we here used a chromatin-directed proteomic approach and identified ZNF84 as a novel regulator of p21 in various p53-deficient cell lines.
HostingRepositoryPRIDE
AnnounceDate2021-09-07
AnnouncementXMLSubmission_2021-09-07_03:22:22.989.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMahmoudreza Rafiee
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListiodoacetamide derivatized residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-11-16 03:38:26ID requested
12021-09-07 03:22:23announced
Publication List
Strzeszewska-Potyra, ł, a A, Staniak K, Czarnecka-Herok J, Rafiee MR, Herok M, Mosieniak G, Krijgsveld J, Sikora E, Chromatin-Directed Proteomics Identifies ZNF84 as a p53-Independent Regulator of p21 in Genotoxic Stress Response. Cancers (Basel), 13(9):(2021) [pubmed]
Keyword List
submitter keyword: CDKN1A, Chromatin-associated proteins, ZNF84
Contact List
Jeroen Krijgsveld
contact affiliationGerman Cancer Research Center (DKFZ), Heidelberg, Germany Medical Faculty, Heidelberg University, Heidelberg, Germany
contact emailj.krijgsveld@dkfz-heidelberg.de
lab head
Mahmoudreza Rafiee
contact affiliationThe Francis Crick Institute
contact emailrafieem@crick.ac.uk
dataset submitter
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Dataset FTP location
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