PXD022537

PXD022537 is an original dataset announced via ProteomeXchange.

Title	Integrated proteomic and transcriptomic analyses reveal the roles of Brucella BI-1 in cell division and membrane homeostasis of Brucella suis S2
Description	To explore the role of Brucella BI-1 in Brucella suis S2, we constructed the Brucella BI-1 deletion mutant strain and its complementary strain. We then determined the effect of Brucella BI-1 deletion on the physiological characteristics of Brucella suis S2 and revealed them via integrated transcriptomic and proteomic analyses. Brucella BI-1 deletion altered the membrane properties of Brucella suis S2 and decreased its resistance to acidic pH, H2O2, polymyxin B, and lincomycin. Additionally, deleting Brucella BI-1 led to defective growth, cell division, and viability in Brucella suis S2. In conclusion, our results revealed that Brucella BI-1 is a bacterial cytoprotective protein involved in membrane homeostasis, cell division, and stress resistance in Brucella suis S2.
HostingRepository	iProX
AnnounceDate	2020-11-13
AnnouncementXML	Submission_2021-02-19_21:10:17.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Guangdong Zhang
SpeciesList	scientific name: Brucella suis bv. 1 str. S2; NCBI TaxID: 1004954;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2020-11-15 19:26:36	ID requested
⏵ 1	2021-02-19 21:10:18	announced

Zhang G, Zhong F, Chen L, Qin P, Li J, Zhi F, Tian L, Zhou D, Lin P, Chen H, Tang K, Liu W, Jin Y, Wang A, S2. Front Microbiol, 12():632095(2021) [pubmed]

submitter keyword: transcriptomics proteomics, Brucella suis S2, BSS2_RS00410

Aihua Wang
contact affiliation	Northwest A&F University
contact email	aihuawang1966@163.com
lab head
Guangdong Zhang
contact affiliation	Northwest A&F University
contact email	gdzhang688@foxmail.com
dataset submitter

iProX dataset URI