PXD022499

PXD022499 is an original dataset announced via ProteomeXchange.

Title	Proteomic analyses of lysine 2-hydroxyisobutyrylation in Fusarium graminearum in response to tebuconazole and carbendazim
Description	Lysine 2-hydroxyisobutyrylation (Khib) is a newly discovered post-translational modification in some prokaryotic and eukaryotic organisms. Here, we carried out proteome-wide analysis of Khib in Fusarium graminearum, identifying the reshaping of lysine 2-hydroxyisobutyrylome by tebuconazole or carbendazim, using the most recently-developed high-resolution LC-MS/MS in combination with high-specific affinity enrichment. In total, 3035 quantifiable Khib sites on 937 proteins were identified. With the criteria of fold changes over 1.3, normalized with total proteins, 1083 Khib sites of 509 proteins were considered as significantly affected by tebuconazole treatment, while 344 Khib sites of 227 proteins were significantly affacted by carbendazim. Furthermore, bioinformatics analysis were conducted.
HostingRepository	PRIDE
AnnounceDate	2022-05-25
AnnouncementXML	Submission_2022-05-25_07:08:13.411.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yanxiang Zhao
SpeciesList	scientific name: Fusarium graminearum PH-1; NCBI TaxID: 229533;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2020-11-13 03:12:27	ID requested
⏵ 1	2022-05-25 07:08:14	announced

Zhao Y, Zhang L, Ju C, Zhang X, Huang J, Quantitative multiplexed proteomics analysis reveals reshaping of the lysine 2-hydroxyisobutyrylome in Fusarium graminearum by tebuconazole. BMC Genomics, 23(1):145(2022) [pubmed]

submitter keyword: 2-hydroxyisobutyrylation

Fusarium graminearum

tebuconazole

carbendazim

Jinguang Huang
contact affiliation	Key Lab of Integrated Crop Disease and Pest Management of Shandong Province; College of Plant Health Medicine, Qingdao Agricultural University
contact email	jghuang@qau.edu.cn
lab head
Yanxiang Zhao
contact affiliation	Qingdao Agricultural University
contact email	zhaoyx@qau.edu.cn
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD022499
     1. Label: PRIDE project
     2. Name: Proteomic analyses of lysine 2-hydroxyisobutyrylation in Fusarium graminearum in response to tebuconazole and carbendazim