PXD022400

PXD022400 is an original dataset announced via ProteomeXchange.

Title	Venom proteome of the limacodid caterpillar Doratifera vulnerans
Description	Caterpillars of moths in the family Limacodidae produce pain-inducing defensive venoms that have evolved independently to previously characterised lepidopteran venoms, but their composition and mechanism of action are unknown. Here, we examine the limacodid venom system using the species Doratifera vulnerans as a model. Large secretory cells at the base of each spine produce a complex venom (151 proteinaceous toxins in 59 families) that consists predominantly of peptides <10 kDa. Three abundant families of venom peptides (vulnericins) are analogues of adipokinetic hormone/corazonin-like neurohormone that activate the endogenous receptor with picomolar efficacy (Family 1); cationic peptides related to cecropin that disrupt lipid bilayers, induce pain, and kill bacteria and helminths (Family 2); and disulfide-rich knottins (Family 3). Our data reveal convergent molecular evolution between limacodids, hymenopterans, and arachnids, and highlight the potential of Limacodidae for peptide biodiscovery.
HostingRepository	PRIDE
AnnounceDate	2021-04-12
AnnouncementXML	Submission_2021-04-12_07:45:58.148.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Andrew Walker
SpeciesList	scientific name: Doratifera vulnerans; NCBI TaxID: 1372962;
ModificationList	amidated residue; 2-pyrrolidone-5-carboxylic acid (Gln)
Instrument	TripleTOF 5600; TripleTOF 6600

Revision	Datetime	Status	ChangeLog Entry
0	2020-11-06 01:39:17	ID requested
⏵ 1	2021-04-12 07:45:58	announced

Dataset with its publication pending

submitter keyword: venom

Lepidoptera

Limacodidae

caterpillar

peptide

toxin

Glenn F. King
contact affiliation	NHMRC Principal Research Fellow Editor-in-Chief, Toxicon & Toxicon:X Theme Leader, Australian Research Council Centre of Excellence for Innovations in Peptide & Protein Science Deputy Head, Division of Chemistry & Structural Biology Institute for Molecular Bioscience The University of Queensland
contact email	glenn.king@imb.uq.edu.au
lab head
Andrew Walker
contact affiliation	University of Queensland
contact email	a.walker@uq.edu.au
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/04/PXD022400

PRIDE project URI

• PRIDE
  1. PXD022400
     1. Label: PRIDE project
     2. Name: Venom proteome of the limacodid caterpillar Doratifera vulnerans