PXD022349

PXD022349 is an original dataset announced via ProteomeXchange.

Title	Protein profiling of CAST.APP/PS1 mouse brain-derived Extracellular vesicles
Description	Extracellular vesicles (EVs) are secreted by any neuronal cells in the central nervous system (CNS) for molecular clearance, cellular communications and disease spread in multiple neurodegenerative diseases, including Alzheimer’s disease (AD), although their exact molecular mechanism is poorly understood. We hypothesize that high-resolution proteomic profiling of EVs separated from animal models of AD would determine the composition of EV contents and their cellular origin.
HostingRepository	PRIDE
AnnounceDate	2021-09-09
AnnouncementXML	Submission_2021-09-09_13:21:55.158.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Satoshi Muraoka
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2020-11-04 07:29:14	ID requested
⏵ 1	2021-09-09 13:21:55	announced

Muraoka S, Jedrychowski MP, Iwahara N, Abdullah M, Onos KD, Keezer KJ, Hu J, Ikezu S, Howell GR, Gygi SP, Ikezu T, Enrichment of Neurodegenerative Microglia Signature in Brain-Derived Extracellular Vesicles Isolated from Alzheimer's Disease Mouse Models. J Proteome Res, 20(3):1733-1743(2021) [pubmed]

submitter keyword: APP/PS1 mouse, brain tissue, extracellular vesicles, TMT label, LC-MSMSMS

Tsuneya Ikezu
contact affiliation	Departments of Pharmacology & Experimental Therapeutics and Neurology Boston University School of Medicine
contact email	tikezu@bu.edu
lab head
Satoshi Muraoka
contact affiliation	Boston University School of Medicine
contact email	smuraoka@bu.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/09/PXD022349

PRIDE project URI

• PRIDE
  1. PXD022349
     1. Label: PRIDE project
     2. Name: Protein profiling of CAST.APP/PS1 mouse brain-derived Extracellular vesicles