PXD022316

PXD022316 is an original dataset announced via ProteomeXchange.

Title	Fast skeletal myosin binding protein-C regulates fast skeletal muscle contraction
Description	Myosin-binding protein C (MyBP-C) is a thick filament regulatory protein found exclusively in the C-zone of the A band in the sarcomeres of vertebrate striated muscle. Cardiac, slow skeletal and fast skeletal MyBP-C (fMyBP-C) paralogs perform different functions. However, the functional role of fMyBP-C in fast skeletal muscle is completely unknown. Genetic mutations in human fMyBP-C lead to skeletal myopathies. All three isoforms share similar protein structures, but likely differ substantially in terms of expression and function, which may serve the distinct physiologies of fast and slow muscle fibers. In the present study, we developed a novel fMyBP-C global knockout (KO) mouse model (C2-/-) to investigate the structural, functional, molecular, cellular and physiological roles of fMyBP-C in skeletal muscle.
HostingRepository	PRIDE
AnnounceDate	2021-04-09
AnnouncementXML	Submission_2021-04-08_23:03:00.578.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sheng Zhang
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2020-11-03 05:31:12	ID requested
⏵ 1	2021-04-08 23:03:00	announced

Dataset with its publication pending

submitter keyword: skeletal myosin binding protein-C, proteomics, LC MS/MS, muscle

Sheng Zhang
contact affiliation	Proteomics and Metabolomics facility, Cornell University
contact email	sz14@cornell.edu
lab head
Sheng Zhang
contact affiliation	Cornell University
contact email	sz14@cornell.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD022316
     1. Label: PRIDE project
     2. Name: Fast skeletal myosin binding protein-C regulates fast skeletal muscle contraction