PXD022262

PXD022262 is an original dataset announced via ProteomeXchange.

Title	Exercise plasma dampens brain inflammation via clusterin and boosts memory
Description	Physical exercise seems universally beneficial to human and animal health, slowing cognitive aging and neurodegeneration. Cognitive benefits are tied to increased plasticity and reduced inflammation within the hippocampus, yet little is known about the factors and mechanisms mediating these effects. We discovered “runner” plasma, collected from voluntarily running mice, infused into sedentary mice recapitulates the cellular and functional benefits of exercise on the adult brain. Importantly, runner plasma reduces baseline neuroinflammatory gene expression and experimentally induced brain inflammation. Plasma proteomic analysis revealed a striking increase in complement cascade inhibitors including clusterin (CLU), which is facilitating the anti-inflammatory effects of runner plasma. Intravenously injected CLU strongly binds to brain endothelial cells reducing their inflammatory gene expression in an acute model of brain inflammation and in Alzheimer’s disease model mice. Cognitively impaired patients participating in structured exercise for 6 months showed improved cognition and higher plasma clusterin levels. These findings demonstrate the existence of anti-inflammatory “exercise factors” that are transferrable, target the cerebrovasculature and benefit the brain, and are present in humans engaging in exercise.
HostingRepository	PRIDE
AnnounceDate	2021-12-22
AnnouncementXML	Submission_2022-01-05_03:51:52.317.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Niclas Olsson
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; N-acetylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2020-10-30 02:26:59	ID requested
1	2021-12-22 11:25:19	announced
⏵ 2	2022-01-05 03:51:53	announced	2022-01-05: Updated publication reference for PubMed record(s): 34880498.

De Miguel Z, Khoury N, Betley MJ, Lehallier B, Willoughby D, Olsson N, Yang AC, Hahn O, Lu N, Vest RT, Bonanno LN, Yerra L, Zhang L, Saw NL, Fairchild JK, Lee D, Zhang H, McAlpine PL, Contrepois K, Shamloo M, Elias JE, Rando TA, Wyss-Coray T, Exercise plasma boosts memory and dampens brain inflammation via clusterin. Nature, 600(7889):494-499(2021) [pubmed]

submitter keyword: Mouse, plasma, LC-MSMS

Tony Wyss-Coray
contact affiliation	Stanford University School of Medicine, Department of Neurology and Neurological Sciences, Stanford, CA 94305, USA
contact email	twc@stanford.edu
lab head
Niclas Olsson
contact affiliation	Stanford University
contact email	nic.e.olsson@gmail.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD022262
     1. Label: PRIDE project
     2. Name: Exercise plasma dampens brain inflammation via clusterin and boosts memory