PXD022218 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomics of aqueous humor for biomarkers discovery in retinoblastoma |
Description | Background: Recent therapeutic advances have greatly improved the eye preservation rate in patients affected by retinoblastoma (RB), however local tumor control remains more difficult in the presence of resistant and/or relapsing retinal or vitreous disease. Thus, the identification of new biomarkers is crucial to design more effective treatment approaches. Recently, technological advances have allowed to safely recover aqueous humor (AH) from patients affected by RB undergoing local treatment. Methods: in order to identify specific proteins associated to active vitreous seeding, we have performed proteomic analysis of AH samples derived from patients affected by RB in different disease stages. Fifty-five AH samples were firstly included in this study. A new widened cohort was then used to validate the proteins identified in the previous discovery set. Results: a total of 808 and 630 proteins were identified in the two analysis, respectively. Five proteins resulted more expressed in the active vitreous seeding group: C19orf57, Girdin, SRFBP, GULP-1 and DCD. These proteins are involved in cytoskeleton regulation, tumor proliferation and growth, invasion and migration of cancer cells. Conclusion: reliable prognostic biomarkers are needed to guide RB management. Proteomic analysis of AH provide a unique opportunity to identify tumor associated biomarkers in patients with RB. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_08:36:48.764.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Andrea Petretto |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-10-28 03:12:00 | ID requested | |
1 | 2023-03-10 20:17:56 | announced | |
⏵ 2 | 2023-11-14 08:36:52 | announced | 2023-11-14: Updated project metadata. |
Publication List
Galardi A, Stathopoulos C, Colletti M, Lavarello C, Russo I, Cozza R, Romanzo A, Carcaboso AM, Locatelli F, Petretto A, Munier FL, Di Giannatale A, Proteomics of Aqueous Humor as a Source of Disease Biomarkers in Retinoblastoma. Int J Mol Sci, 23(21):(2022) [pubmed] |
Keyword List
submitter keyword: proteomic analysis,Retinoblastoma, humor aqueous, biomarkers |
Contact List
Andrea Petretto |
contact affiliation | Ist. G. Gaslini |
contact email | a.petretto@gmail.com |
lab head | |
Andrea Petretto |
contact affiliation | Gaslini Children's Hospital |
contact email | a.petretto@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD022218
- Label: PRIDE project
- Name: Proteomics of aqueous humor for biomarkers discovery in retinoblastoma