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PXD022218

PXD022218 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomics of aqueous humor for biomarkers discovery in retinoblastoma
DescriptionBackground: Recent therapeutic advances have greatly improved the eye preservation rate in patients affected by retinoblastoma (RB), however local tumor control remains more difficult in the presence of resistant and/or relapsing retinal or vitreous disease. Thus, the identification of new biomarkers is crucial to design more effective treatment approaches. Recently, technological advances have allowed to safely recover aqueous humor (AH) from patients affected by RB undergoing local treatment. Methods: in order to identify specific proteins associated to active vitreous seeding, we have performed proteomic analysis of AH samples derived from patients affected by RB in different disease stages. Fifty-five AH samples were firstly included in this study. A new widened cohort was then used to validate the proteins identified in the previous discovery set. Results: a total of 808 and 630 proteins were identified in the two analysis, respectively. Five proteins resulted more expressed in the active vitreous seeding group: C19orf57, Girdin, SRFBP, GULP-1 and DCD. These proteins are involved in cytoskeleton regulation, tumor proliferation and growth, invasion and migration of cancer cells. Conclusion: reliable prognostic biomarkers are needed to guide RB management. Proteomic analysis of AH provide a unique opportunity to identify tumor associated biomarkers in patients with RB.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_08:36:48.764.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterAndrea Petretto
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-10-28 03:12:00ID requested
12023-03-10 20:17:56announced
22023-11-14 08:36:52announced2023-11-14: Updated project metadata.
Publication List
Galardi A, Stathopoulos C, Colletti M, Lavarello C, Russo I, Cozza R, Romanzo A, Carcaboso AM, Locatelli F, Petretto A, Munier FL, Di Giannatale A, Proteomics of Aqueous Humor as a Source of Disease Biomarkers in Retinoblastoma. Int J Mol Sci, 23(21):(2022) [pubmed]
Keyword List
submitter keyword: proteomic analysis,Retinoblastoma, humor aqueous, biomarkers
Contact List
Andrea Petretto
contact affiliationIst. G. Gaslini
contact emaila.petretto@gmail.com
lab head
Andrea Petretto
contact affiliationGaslini Children's Hospital
contact emaila.petretto@gmail.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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