PXD022140

PXD022140 is an original dataset announced via ProteomeXchange.

Title	A new panel of pancreatic cancer biomarkers discovered using a mass spectrometry-based pipeline
Description	Pancreatic carcinoma (PC) is an aggressive malignancy that lacks strategies for early detection. This study aimed to develop a coherent, high-throughput and non-discriminatory pipeline for the novel clinical biomarker discovery of PC. On the basis of the newly developed pipeline, we identified >1000 proteins, verified 142 differentially expressed proteins and finally targeted four proteins for absolute quantitation in 100 serum samples. The novel biomarker panel of apolipoprotein E (APOE), inter-alpha-trypsin inhibitor heavy chain H3 (ITIH3), apolipoprotein A-I (APOA1), apolipoprotein L1 (APOL1), combining with CA19-9, statistically-significantly improved the sensitivity (95%) and specificity (94.1%), outperforming CA19-9 alone, for the diagnosis of PC.
HostingRepository	iProX
AnnounceDate	2020-10-23
AnnouncementXML	Submission_2020-10-22_22:03:39.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xiaohui Liu
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	iTRAQ8plex reporter+balance reagent acylated residue
Instrument	TripleTOF 5600; Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2020-10-22 22:01:45	ID requested
⏵ 1	2020-10-22 22:03:40	announced

Liu X, Zheng W, Wang W, Shen H, Liu L, Lou W, Wang X, Yang P, A new panel of pancreatic cancer biomarkers discovered using a mass spectrometry-based pipeline. Br J Cancer, 117(12):1846-1854(2017) [pubmed]

submitter keyword: pancreatic cancer, serum, biomarker, mass spectrometry, LC-MS, MRM

Pengyuan Yang
contact affiliation	Institute of Biomedical science
contact email	pyyang@fudan.edu.cn
lab head
Xiaohui Liu
contact affiliation	Fudan University
contact email	liuxiaohui@fudan.edu.cn
dataset submitter

iProX dataset URI