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PXD022139

PXD022139 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleNovel Insights into Candidate Biomarkers in Patients with Chronic Mountain Sickness Based on Proteomics
DescriptionChronic mountain sickness (CMS) is a progressive incapacitating syndrome induced by lifelong exposure to hypoxia. In the present study, proteomic analysis was used to identify the differential expression proteins (DEPs) and then evaluate the potential biomarkers between CMS and non-CMS groups. A total of 145 DEPs were detected among CMS Han Chinese people who live in the plateau (CMS-HPu), among which 89 were significantly upregulated and 56 were significantly downregulated. GO enrichment analysis showed that various biological processes were enriched, including the hydrogen peroxide metabolic/catabolic process and reactive oxygen species (ROS) metabolic and acute inflammatory response. Protein–protein interaction analysis showed that antioxidant activity, the hydrogen peroxide catabolic process, and peroxidase activity were primarily mapped in interaction proteins. Nine modules showed significant clustering based on WGCNA analysis, with two being the most significant, and GO analysis showed that proteins of both modules were primarily enriched in oxidative stress-related biological processes. Four DEPs whose activities were increased in CMS patients were evaluated as the candidate biomarkers, especially the hemoglobin beta chain (HB-β), thioredoxin-1 (TRX1), and phosphoglycerate kinase 1 (PGK1). This study provides novel insights into the pathogenesis of CMS and further evaluates the potential biomarkers for its prevention and treatment.
HostingRepositoryiProX
AnnounceDate2020-10-22
AnnouncementXMLSubmission_2023-03-02_18:29:11.136.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterZhen Chen
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListiTRAQ4plex reporter+balance reagent acylated residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-10-22 21:09:36ID requested
12020-10-22 21:11:31announced
22023-03-02 18:29:12announced2023-03-03: Update publication information.
Publication List
Zhang P, Li Z, Yang F, Ji L, Yang Y, Liu C, Liu H, Ma J, Liu J, Dang Z, Wang S, Ge R, Cui S, Novel insights into plasma biomarker candidates in patients with chronic mountain sickness based on proteomics. Biosci Rep, 41(1):(2021) [pubmed]
Keyword List
submitter keyword: Chronic mountain sickness, Hemoglobin beta chain, Thioredoxin-1, Phosphoglycerate kinase 1, Proteomics, Oxidative stress
Contact List
Zhen Chen
contact affiliationShenzhen Omics Research Center
contact emailomics_shenzhen@163.com
lab head
Zhen Chen
contact affiliationShenzhen Omics Research Center
contact emailOmics_shenzhen@163.com
dataset submitter
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