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PXD022131

PXD022131 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleNetwork-based integration of multi-omics data identifies the determinants of miR-491-5p effects
DescriptionThe identification of miRNAs’ targets and associated regulatory networks might allow the definition of new strategies using drugs whose association might mimic a given miRNA’s effects. Based on this assumption our group devised a multi-omics approach in an attempt to precisely characterize miRNAs’ effects. We combined the analysis of miR-491-5p direct targets, and effects at the transcriptomic and proteomic levels. We thus constructed an interaction network which enlightened highly connected nodes, being either direct or indirect targets of miR-491-5p effects: the already known EGFR and BCL2L1, but also EP300, CTNNB1 and several small-GTPases. By using different combinations of specific inhibitors of these nodes, we could greatly enhance their respective cytotoxicity and mimic miR-491-5p-induced phenotype. Our methodology thus constitutes an interesting strategy to comprehensively study the effects of a given miRNA. Also, we identified targets for which pharmacological inhibitors are already available for a clinical use, or in clinical trial phases. This study might thus enable innovative therapeutic options for ovarian cancer, which remains the first cause of death from gynecological malignancies in developed countries.
HostingRepositoryPRIDE
AnnounceDate2021-09-09
AnnouncementXMLSubmission_2021-09-09_10:41:29.240.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterValentin SABATET
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList6x(13)C labeled residue
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-10-22 01:35:57ID requested
12021-09-09 10:41:30announced
Publication List
Meryet-Figuiere M, Vernon M, Andrianteranagna M, Lambert B, Brochen C, Issartel JP, Guttin A, Gauduchon P, Brotin E, Dingli F, Loew D, Vigneron N, Wambecke A, Abeilard E, Barillot E, Poulain L, Martignetti L, Denoyelle C, Network-Based Integration of Multi-Omics Data Identifies the Determinants of miR-491-5p Effects. Cancers (Basel), 13(16):(2021) [pubmed]
Keyword List
submitter keyword: Network, Multi-omics, miRNA, Ovarian Cancer
Contact List
Damarys Loew
contact affiliationHead of the Mass Spectrometry plateform of the Institut Curie (LSMP)
contact emaildamarys.loew@curie.fr
lab head
Valentin SABATET
contact affiliationCurie Institute
contact emailvalentin.sabatet@curie.fr
dataset submitter
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Dataset FTP location
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