PXD022126

PXD022126 is an original dataset announced via ProteomeXchange.

Title	Damaged Brain Accelerates Bone Healing by Releasing Exosomes that Target Osteoprogenitors
Description	Clinical evidence has established that concomitant traumatic brain injury accelerates bone healing, but the underlying mechanism is unclear. This study showed that after TBI, injured neurons, mainly those in the hippocampus, released osteogenic microRNA (miRNA)-enriched exosomes, which targeted osteoprogenitors in bone to stimulate bone formation. Importantly, increased fibronectin expression on exosomal surface contributed to targeting of osteoprogenitors in bone by TBI exosomes, thereby implying that modification of the exosome surface fibronectin could be used in bone-targeted drug delivery. Together, our findings have established a novel role of central regulation in bone formation and a clear link between injured neurons and osteogenitors, both in animals and clinical settings.
HostingRepository	PRIDE
AnnounceDate	2021-07-13
AnnouncementXML	Submission_2021-07-12_22:14:41.499.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Wei Xia
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2020-10-21 22:46:56	ID requested
⏵ 1	2021-07-12 22:14:41	announced

Dataset with its publication pending

submitter keyword: Exosomes，bone healing，injured neurons

Xiao-Chun Bai
contact affiliation	Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China
contact email	baixc15@smu.edu.cn
lab head
Wei Xia
contact affiliation	Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China
contact email	xiawei123456@126.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/07/PXD022126

PRIDE project URI

• PRIDE
  1. PXD022126
     1. Label: PRIDE project
     2. Name: Damaged Brain Accelerates Bone Healing by Releasing Exosomes that Target Osteoprogenitors