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PXD022046

PXD022046 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleDelaying aging and enhancing repair of the aged CNS myelin by β-NMN requires SIRT2
DescriptionMyelin aging is a driving force of CNS aging, and age-dependent declined efficiency of remyelination caused by impaired differentiation capacity of aged oligodendrocyte precursor cell (OPC) is a major cause of demyelinated diseases. Revealing how differentiation capacity of aged OPC is affected metabolically holds the key to find new way to rejuvenate the aged OPC. Here we screened out that NAD+ is one of the top metabolites impaired in premature aging OPC. Supplementing β-nicotinamide mononucleotide (β-NMN), an immediate NAD+ precursor, delays CNS myelin aging, promotes differentiation of aged OPC, and therapeutically and preventively rejuvenates remyelination in the aged CNS both ultra-structurally and functionally. To explore the molecular mechanisms underlying the enhancing remyelination by NAD+ supplementation, using LC-MS we investigated the changes of proteome differentially regulated by NAD+ or DMSO in cultured OPC from P0 rat brain.
HostingRepositoryiProX
AnnounceDate2020-10-18
AnnouncementXMLSubmission_2023-02-20_19:24:30.938.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterXiao-Ru Ma
SpeciesList scientific name: Rattus norvegicus; NCBI TaxID: 10116;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-10-18 05:34:33ID requested
12020-10-18 05:36:44announced
22023-02-20 19:24:31announced2023-02-21: Update information.
Publication List
Ma XR, Zhu X, Xiao Y, Gu HM, Zheng SS, Li L, Wang F, Dong ZJ, Wang DX, Wu Y, Yang C, Jiang W, Yao K, Yin Y, Zhang Y, Peng C, Gao L, Meng Z, Hu Z, Liu C, Li L, Chen HZ, Shu Y, Ju Z, Zhao JW, Restoring nuclear entry of Sirtuin 2 in oligodendrocyte progenitor cells promotes remyelination during ageing. Nat Commun, 13(1):1225(2022) [pubmed]
Keyword List
submitter keyword: NAD+, β-nicotinamide mononucleotide, oligodendrocyte precursor cell, differentiation, myelin aging, myelin rejuvenation, remyelination, SIRT2, metabolism, epigenetics
Contact List
Jing-Wei Zhao
contact affiliationZhejiang University School of Medicine
contact emailjingweizhao@zju.edu.cn
lab head
Xiao-Ru Ma
contact affiliationZhejiang University School of Medicine
contact emailmaxiaoru@zju.edu.cn
dataset submitter
Full Dataset Link List
iProX dataset URI