PXD022044 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Mapping and quantification of phosphorylation sites on protein kinase Akt by LC-MS/MS |
Description | Mass spectrometry analysis of various Akt species was a cornerstone for elucidating the mechanism of its activation/autoinhibition. By combining intact mass measurements with LC-MS/MS we were able to characterize Akt species comprehensively and relate their biological activity to specific phosphorylation patterns. |
HostingRepository | PRIDE |
AnnounceDate | 2023-03-20 |
AnnouncementXML | Submission_2023-03-20_04:48:43.400.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | DorotheaAnrather |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | phosphorylated residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-10-16 08:44:33 | ID requested | |
1 | 2021-08-13 01:26:17 | announced | |
⏵ 2 | 2023-03-20 04:48:44 | announced | 2023-03-20: Updated project metadata. |
Publication List
Truebestein L, Hornegger H, Anrather D, Hartl M, Fleming KD, Stariha JTB, Pardon E, Steyaert J, Burke JE, Leonard TA, -mediated activation. Proc Natl Acad Sci U S A, 118(33):(2021) [pubmed] |
Keyword List
submitter keyword: growth factor signaling, PIP3,Akt1, lipid second messengers |
Contact List
Thomas A.Leonard |
contact affiliation | Department of Structural and Computational Biology, Max Perutz Labs, Campus Vienna Biocenter 5, 1030 Vienna, Austria |
contact email | thomas.leonard@medunivie.ac.at |
lab head | |
DorotheaAnrather |
contact affiliation | Max Perutz Labs, Mass Spectrometry Facility, University of Vienna |
contact email | dorothea.anrather@univie.ac.at |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/08/PXD022044 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD022044
- Label: PRIDE project
- Name: Mapping and quantification of phosphorylation sites on protein kinase Akt by LC-MS/MS