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PXD022028

PXD022028 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleHost cholesterol modulates the generation and enrichment of persister population during Mycobacterium tuberculosis infection.
DescriptionPost-translational modifications (PTMs) confer diversity to regulatory mechanisms that control various cellular pathways. Two of the most extensively studied PTMs are phosphorylation and acetylation. Together, they are known to regulate the stability and activity of proteins in both eukaryotes and prokaryotes. Lysine acetylation is known to regulate various cellular pathways conserved across species including mycobacteria. In order to confirm the cholesterol mediated deacetylation of anti-toxin in Mycobacteria, we did mass spectrometry of BCG strain overexpressing the toxin (vapC12)–antitoxin (vapB12)-His(6X) locus grown in glycerol and cholesterol media.
HostingRepositoryPRIDE
AnnounceDate2020-11-02
AnnouncementXMLSubmission_2020-11-02_05:33:41.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterRenu Goel
SpeciesList scientific name: Mycobacterium tuberculosis M24; NCBI TaxID: 1268063;
ModificationListNo PTMs are included in the dataset
InstrumentTripleTOF 5600
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-10-16 03:46:13ID requested
12020-10-16 06:36:54announced
22020-11-02 05:33:41announced2020-11-02: Updated project metadata.
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: proteomics, LC-MS/MS
Contact List
Dr Amit Pandey
contact affiliationTranslational Health Science and Technology Institute
contact emailamitpandey@thsti.res.in
lab head
Renu Goel
contact affiliationTranslational Health Science and technology Institute
contact emaildrrenugoel@gmail.com
dataset submitter
Full Dataset Link List
Dataset FTP location
PRIDE project URI
Repository Record List
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