PXD022001

PXD022001 is an original dataset announced via ProteomeXchange.

Title	Proteome-Wide Analyses Reveal Diverse Functions of Acylation Proteins in Neurospora crassa
Description	Quantitative acetyl-proteomics, a newly identified post-translational modification, is known to regulate transcriptional activity in different organisms. Neurospora crassa is a model ascomycete fungus maintained for biochemistry and molecular biology research; however, extensive studies of the functions of its acylation proteins have yet to be performed. In this study, using LC-MS/MS qualitative proteomics strategies, we identified 1909 modification sites on 940 proteins in N. crassa and analysed the functions of these proteins using GO enrichment, KEGG pathway, and subcellular location experiments. We classified the acetylation protein involvement in diverse pathways, and protein-protein interaction (PPI) network analysis further demonstrated that these proteins participate in diverse biological processes. In summary, our study comprehensively profiles the crosstalk of modified sites, and PPI among these proteins may form a complex network with both similar and distinct regulatory mechanisms, providing improved understanding of their biological functions in N. crassa.
HostingRepository	PRIDE
AnnounceDate	2021-03-04
AnnouncementXML	Submission_2021-03-04_14:13:00.188.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Zhen He
SpeciesList	scientific name: Neurospora crassa; NCBI TaxID: 5141;
ModificationList	acetylated residue
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2020-10-15 01:16:52	ID requested
⏵ 1	2021-03-04 14:13:00	announced

Wang T, Guan W, Du Y, Xu Y, He Z, Zhang Y, Kang C, Wan X, Chi X, Sun K, Zhang X, Proteome-wide analyses reveal diverse functions of acetylation proteins in Neurospora crassa. Proteomics, 21(6):e2000212(2021) [pubmed]

submitter keyword: Neurospora crassa

Quantitative acetyl-proteomics

acetylated proteins

protein-protein interaction

Zhen He
contact affiliation	Yangzhou University
contact email	hezheng225@163.com
lab head
Zhen He
contact affiliation	Yangzhou University
contact email	hezheng225@163.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD022001
     1. Label: PRIDE project
     2. Name: Proteome-Wide Analyses Reveal Diverse Functions of Acylation Proteins in Neurospora crassa