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PXD021993

PXD021993 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleThe Secretome of Liver X Receptor Agonist Treated Early Outgrowth Cells Decreases Atherosclerosis in Ldlr-/- Mice
DescriptionEndothelial progenitor cells (EPCs) promote the maintenance of the endothelium by secreting vasoreparative factors. A population of EPCs known as early outgrowth cells (EOCs) are being investigated as novel cell-based therapies for the treatment of cardiovascular disease. We previously demonstrated that the absence of liver x receptors (LXRs) is detrimental to the formation and function of EOCs under hypercholesterolemic conditions. Here, we investigate whether LXR activation in EOCs is beneficial for the treatment of atherosclerosis. EOCs were differentiated from the bone marrow of wildtype (WT) and LXR-knockout (Lxrαβ-/-) mice in the presence of vehicle or LXR agonist (GW3965). This data set is a proteomic comparison of EPCs at day 1 after isolation and day 9 of GW39565 treatment compared to day 9 of vehicle treatment.
HostingRepositoryPRIDE
AnnounceDate2021-09-09
AnnouncementXMLSubmission_2021-09-09_10:08:19.012.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMichael Saikali
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-10-15 01:15:57ID requested
12021-09-09 10:08:19announced
Publication List
Rasheed A, Shawky SA, Tsai R, Jung RG, Simard T, Saikali MF, Hibbert B, Rayner KJ, Cummins CL, The secretome of liver X receptor agonist-treated early outgrowth cells decreases atherosclerosis in Ldlr-/- mice. Stem Cells Transl Med, 10(3):479-491(2021) [pubmed]
Keyword List
submitter keyword: LXR, EPC, Atherosclerosis, Liver X Receptor, Endothelial Progenitor cells
Contact List
Carolyn Cummins
contact affiliationLeslie Dan Faculty of Pharmacy, University of Toronto
contact emailcarolyn.cummins@utoronto.ca
lab head
Michael Saikali
contact affiliationUniversity of Toronto
contact emailmichael.saikali@mail.utoronto.ca
dataset submitter
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Dataset FTP location
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Repository Record List
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