PXD021983

PXD021983 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Tension mediated mechanical activation and pocket delipidation lead to an analogous MscL channel state
Description	We present HDX-MS data of WT and L89W TbMscL to interrogate the mechanism of molecular activation in this mechanosensitive channel.
HostingRepository	PRIDE
AnnounceDate	2022-06-07
AnnouncementXML	Submission_2022-06-07_02:35:43.661.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Antonio Calabrese
SpeciesList	scientific name: Mycobacterium tuberculosis EAI/OSDD271; NCBI TaxID: 1322343;
ModificationList	No PTMs are included in the dataset
Instrument	Synapt MS

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2020-10-14 23:23:34	ID requested
⏵ 1	2022-06-07 02:35:45	announced

Publication List

Wang B, Lane BJ, Kapsalis C, Ault JR, Sobott F, El Mkami H, Calabrese AN, Kalli AC, Pliotas C, Pocket delipidation induced by membrane tension or modification leads to a structurally analogous mechanosensitive channel state. Structure, 30(4):608-622.e5(2022) [pubmed]

Wang B, Lane BJ, Kapsalis C, Ault JR, Sobott F, El Mkami H, Calabrese AN, Kalli AC, Pliotas C, Pocket delipidation induced by membrane tension or modification leads to a structurally analogous mechanosensitive channel state. Structure, 30(4):608-622.e5(2022) [pubmed]

Keyword List

submitter keyword: tension, mechanosensation, MscL, HDX-MS

submitter keyword: tension, mechanosensation, MscL, HDX-MS

Contact List

Antonio Calabrese
contact affiliation	School of Molecular and Cellular Biology Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, United Kingdom
contact email	a.calabrese@leeds.ac.uk
lab head
Antonio Calabrese
contact affiliation	School of Molecular and Cellular Biology, University of Leeds
contact email	a.calabrese@leeds.ac.uk
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/06/PXD021983
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/06/PXD021983

PRIDE project URI

Repository Record List

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