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PXD021920

PXD021920 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomic analysis of hippocampal synaptosomes in chronically socially isolated rats: effect of antidepressant tianeptine
DescriptionDysregulation of brain synaptic proteins caused by chronic psychosocial stress has been linked with the development of major depression (MD). To gain insights into the pattern of synaptic proteome changes and different biological functions and pathways underlying MD and drug action, a comparative proteomic approach was employed in the hippocampus of rats exposed to chronic social isolation (CSIS, 6 weeks), an animal model of depression, with or without chronic antidepressant tianeptine (Tian) treatment (last 3 weeks of CSIS).
HostingRepositoryPRIDE
AnnounceDate2022-02-16
AnnouncementXMLSubmission_2022-02-16_08:19:30.570.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterVictor Costina
SpeciesList scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationListiodoacetamide derivatized residue
InstrumentLTQ Orbitrap
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-10-12 06:54:55ID requested
12022-02-16 08:19:34announced
Publication List
Peri, ć I, Costina V, Djordjevi, ć S, Gass P, Findeisen P, Inta D, Borgwardt S, Filipovi, ć D, Tianeptine modulates synaptic vesicle dynamics and favors synaptic mitochondria processes in socially isolated rats. Sci Rep, 11(1):17747(2021) [pubmed]
Keyword List
submitter keyword: Rat, Hippocampus, Proteomics, LC-MS/MS
Contact List
Prof. Dr. Peter Findeisen
contact affiliationInstitut of Clinical Chemistry
contact emailPeter.Findeisen@medma.uni-heidelberg.de
lab head
Victor Costina
contact affiliationInstitute for Clinical Chemistry, Medical Faculty Mannheim of the University of Heidelberg
contact emailVictor.Costina@medma.uni-heidelberg.de
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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