PXD021920

PXD021920 is an original dataset announced via ProteomeXchange.

Title	Proteomic analysis of hippocampal synaptosomes in chronically socially isolated rats: effect of antidepressant tianeptine
Description	Dysregulation of brain synaptic proteins caused by chronic psychosocial stress has been linked with the development of major depression (MD). To gain insights into the pattern of synaptic proteome changes and different biological functions and pathways underlying MD and drug action, a comparative proteomic approach was employed in the hippocampus of rats exposed to chronic social isolation (CSIS, 6 weeks), an animal model of depression, with or without chronic antidepressant tianeptine (Tian) treatment (last 3 weeks of CSIS).
HostingRepository	PRIDE
AnnounceDate	2022-02-16
AnnouncementXML	Submission_2022-02-16_08:19:30.570.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Victor Costina
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	iodoacetamide derivatized residue
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2020-10-12 06:54:55	ID requested
⏵ 1	2022-02-16 08:19:34	announced

Peri, ć I, Costina V, Djordjevi, ć S, Gass P, Findeisen P, Inta D, Borgwardt S, Filipovi, ć D, Tianeptine modulates synaptic vesicle dynamics and favors synaptic mitochondria processes in socially isolated rats. Sci Rep, 11(1):17747(2021) [pubmed]

submitter keyword: Rat, Hippocampus, Proteomics, LC-MS/MS

Prof. Dr. Peter Findeisen
contact affiliation	Institut of Clinical Chemistry
contact email	Peter.Findeisen@medma.uni-heidelberg.de
lab head
Victor Costina
contact affiliation	Institute for Clinical Chemistry, Medical Faculty Mannheim of the University of Heidelberg
contact email	Victor.Costina@medma.uni-heidelberg.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD021920

PRIDE project URI

• PRIDE
  1. PXD021920
     1. Label: PRIDE project
     2. Name: Proteomic analysis of hippocampal synaptosomes in chronically socially isolated rats: effect of antidepressant tianeptine