PXD021920 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomic analysis of hippocampal synaptosomes in chronically socially isolated rats: effect of antidepressant tianeptine |
Description | Dysregulation of brain synaptic proteins caused by chronic psychosocial stress has been linked with the development of major depression (MD). To gain insights into the pattern of synaptic proteome changes and different biological functions and pathways underlying MD and drug action, a comparative proteomic approach was employed in the hippocampus of rats exposed to chronic social isolation (CSIS, 6 weeks), an animal model of depression, with or without chronic antidepressant tianeptine (Tian) treatment (last 3 weeks of CSIS). |
HostingRepository | PRIDE |
AnnounceDate | 2022-02-16 |
AnnouncementXML | Submission_2022-02-16_08:19:30.570.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Victor Costina |
SpeciesList | scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116; |
ModificationList | iodoacetamide derivatized residue |
Instrument | LTQ Orbitrap |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-10-12 06:54:55 | ID requested | |
⏵ 1 | 2022-02-16 08:19:34 | announced | |
Publication List
Peri, ć I, Costina V, Djordjevi, ć S, Gass P, Findeisen P, Inta D, Borgwardt S, Filipovi, ć D, Tianeptine modulates synaptic vesicle dynamics and favors synaptic mitochondria processes in socially isolated rats. Sci Rep, 11(1):17747(2021) [pubmed] |
Keyword List
submitter keyword: Rat, Hippocampus, Proteomics, LC-MS/MS |
Contact List
Prof. Dr. Peter Findeisen |
contact affiliation | Institut of Clinical Chemistry |
contact email | Peter.Findeisen@medma.uni-heidelberg.de |
lab head | |
Victor Costina |
contact affiliation | Institute for Clinical Chemistry, Medical Faculty Mannheim of the University of Heidelberg |
contact email | Victor.Costina@medma.uni-heidelberg.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD021920 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD021920
- Label: PRIDE project
- Name: Proteomic analysis of hippocampal synaptosomes in chronically socially isolated rats: effect of antidepressant tianeptine