PXD021898

PXD021898 is an original dataset announced via ProteomeXchange.

Title	Systematic analysis of MYC regulators identifies AKIRIN2 as an essential mediator of nuclear proteasome import
Description	AKIRIN2 is an essential negative regulator of MYC protein levels. To test the specificity of AKIRIN2-dependent MYC regulation we performed unbiased protein quantification after inducible AKIRIN2- or Proteasome knockout und identified subsets of proteins accumulating after loss of AKIRIN2, Proteasomes or both.
HostingRepository	PRIDE
AnnounceDate	2023-05-14
AnnouncementXML	Submission_2023-05-14_14:16:18.574.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	RichardImre
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue; deamidated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2020-10-08 06:51:33	ID requested
1	2021-11-02 05:44:19	announced
2	2022-02-14 03:31:56	announced	2022-02-14: Updated project metadata.
⏵ 3	2023-05-14 14:16:18	announced	2023-05-14: Updated project metadata.

Dataset with its publication pending

ProteomeXchange project tag: EPIC-XS

submitter keyword: inducible Cas9, AKIRIN2,Proteasome

JohannesZuber
contact affiliation	Research Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), 1030 Vienna, Austria Medical University of Vienna, Vienna BioCenter (VBC), 1030 Vienna, Austria
contact email	johannes.zuber@imp.ac.at
lab head
RichardImre
contact affiliation	Mass Spectrometry - Protein Chemistry Facility IMBA - Institute of Molecular Biotechnology Vienna Biocenter, Dr. Bohrgasse 3, A-1030 Wien, Austria
contact email	richardimre@hotmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/11/PXD021898

PRIDE project URI

• PRIDE
  1. PXD021898
     1. Label: PRIDE project
     2. Name: Systematic analysis of MYC regulators identifies AKIRIN2 as an essential mediator of nuclear proteasome import