PXD021896

PXD021896 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Proteomic analysis of SARS-CoV-2: A clinical landscape of COVID-19 proteome and host responses
Description	A novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of COVID-19 and continues to be a global health challenge. To understand viral disease biology, we have carried out proteo-genomic analysis using next generation sequencing (NGS) and mass-spectrometry on nasopharyngeal swabs of COVID-19 patients to examine clinical genome and proteome. Our proteomic analysis, for the first time identified 13 different SARS-CoV-2 proteins from the clinical swabs. Additionally, host proteome analysis revealed several key host proteins to be uniquely expressed in COVID-19 patients. Besides revealing aspects of host-virus pathogenesis, our study opens avenues to develop better diagnostic markers and therapeutic strategies.
HostingRepository	PRIDE
AnnounceDate	2024-10-08
AnnouncementXML	Submission_2024-10-08_11:14:58.756.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD021896
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Sathisha Kamanna
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Agilent MassHunter format; 6520A Quadrupole Time-of-Flight LC/MS

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2020-10-08 06:48:23	ID requested
⏵ 1	2024-10-08 11:14:59	announced

Publication List

10.6019/PXD021896;
10.1021/acs.jproteome.0c00808;
Tushir S, Kamanna S, Nath SS, Bhat A, Rose S, Aithal AR, Tatu U, Proteo-Genomic Analysis of SARS-CoV-2: A Clinical Landscape of Single-Nucleotide Polymorphisms, COVID-19 Proteome, and Host Responses. J Proteome Res, 20(3):1591-1601(2021) [pubmed]

10.6019/PXD021896;

10.1021/acs.jproteome.0c00808;

Tushir S, Kamanna S, Nath SS, Bhat A, Rose S, Aithal AR, Tatu U, Proteo-Genomic Analysis of SARS-CoV-2: A Clinical Landscape of Single-Nucleotide Polymorphisms, COVID-19 Proteome, and Host Responses. J Proteome Res, 20(3):1591-1601(2021) [pubmed]

Keyword List

ProteomeXchange project tag: Sars-cov-2, Covid-19
submitter keyword: SARS-CoV-2, COVID-19 proteins, clinical swabs, LC-MS/MS analysis, Proteome/host response

ProteomeXchange project tag: Sars-cov-2, Covid-19

submitter keyword: SARS-CoV-2, COVID-19 proteins, clinical swabs, LC-MS/MS analysis, Proteome/host response

Contact List

Utpal Tatu
contact affiliation	Department of Biochemistry, Indian Institute of Science, Bangalore 560012 ph no. 08022932823
contact email	tatu@iisc.ac.in
lab head
Sathisha Kamanna
contact affiliation	INDIAN INSTITUTE OF SCIENCE
contact email	satishkmb@gmail.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/06/PXD021896
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/06/PXD021896

PRIDE project URI

Repository Record List

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