PXD021868

PXD021868 is an original dataset announced via ProteomeXchange.

Title	Bifidobacterium infantis metabolizes 2´fucosyllactose-derived and free fucose through a common catabolic pathway resulting in 1,2-propanediol secretion
Description	Human milk oligosaccharides (HMOs) are highly diverse complex carbohydrates secreted in human milk. HMOs are indigestible by the infant and instead are metabolized by bifidobacteria in the infant gut microbiome to produce molecules that promote infant health and development. 2´fucosyllactose (2´FL) is an abundant HMO and is utilized by Bifidobacterium longum subsp. infantis, a predominant member of the infant gut microbiome. Currently, there is not a scientific consensus on how or if bifidobacteria metabolize the fucose portion of 2´FL or free fucose. This proteomic analysis was conducted in order to characterize the metabolic pathway by which B. infantis utilizes fucose.
HostingRepository	PRIDE
AnnounceDate	2021-03-17
AnnouncementXML	Submission_2021-03-16_23:25:32.822.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Asha Rani
SpeciesList	scientific name: Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088; NCBI TaxID: 391904;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2020-10-06 23:16:00	ID requested
⏵ 1	2021-03-16 23:25:33	announced

Dedon LR, Ö, zcan E, Rani A, Sela DA, Metabolizes 2'Fucosyllactose-Derived and Free Fucose Through a Common Catabolic Pathway Resulting in 1,2-Propanediol Secretion. Front Nutr, 7():583397(2020) [pubmed]

ProteomeXchange project tag: Food and Nutrition (B/D-HPP)

submitter keyword: Bifidobacteria, human milk oligosaccharides, fucose, 2'fucosyllactose, microbiota, microbiome

David A. Sela
contact affiliation	Associate Professor, Dept. of Food Science Adjunct Associate Professor, Dept. of Microbiology University of Massachusetts Amherst Adjunct Associate Professor, Dept. of Microbiology & Physiological Systems University of Massachusetts Medical School selalab.org 413.545.1010
contact email	davidsela@umass.edu
lab head
Asha Rani
contact affiliation	University of Massachusetts Amherst
contact email	arani@umass.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/03/PXD021868

PRIDE project URI

• PRIDE
  1. PXD021868
     1. Label: PRIDE project
     2. Name: Bifidobacterium infantis metabolizes 2´fucosyllactose-derived and free fucose through a common catabolic pathway resulting in 1,2-propanediol secretion