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PXD021857

PXD021857 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleHigh-density monitoring of tyrosine phosphorylation signaling targets in human tumors using internal standard triggered targeted quantitation
DescriptionSureQuant pTyr, a targeted, tyrosine phosphorylation (pTyr) mass spectrometry method, was applied to profile the pTyr signatures of human colorectal tumor samples. Using internal standard guided acquisition with the SureQuant acquisition mode on the Oribtrap Exploris 480 mass spectrometer (Thermo Scientific), the real-time detection of trigger peptides during analysis initiates the sensitive and selective quantitation of endogenous pTyr targets. This framework allows for reliable quantification of several hundred commonly dysregulated pTyr targets with high quantitative accuracy and improves the robustness and usability of targeted acquisition.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_05:32:17.303.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterLauren Stopfer
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListphosphorylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-10-06 01:20:20ID requested
12022-02-16 08:24:57announced
22024-10-22 05:32:18announced2024-10-22: Updated project metadata.
Publication List
10.1158/0008-5472.can-20-3804;
Stopfer LE, Flower CT, Gajadhar AS, Patel B, Gallien S, Lopez-Ferrer D, White FM, High-Density, Targeted Monitoring of Tyrosine Phosphorylation Reveals Activated Signaling Networks in Human Tumors. Cancer Res, 81(9):2495-2509(2021) [pubmed]
Keyword List
submitter keyword: cancer,Targeted, phosphorylation, colorectal, signaling
Contact List
Forest White
contact affiliationKoch Institute for Integrate Cancer Research & Department of Biological Engineering, MIT
contact emailfwhite@mit.edu
lab head
Lauren Stopfer
contact affiliationMIT
contact emaillstopfer@mit.edu
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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