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PXD021853 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleWhole Lung Proteome in N. brasiliensis Infection in IL-13 deficient mice.
DescriptionIL-13 plays a key role during protective type 2 immune responses at mucosal sites, such as during infection with nematodes. However, dysregulation of IL-13 can also contribute to the pathogenesis of allergic and fibrotic diseases. Matrix remodelling is an important component of repair processes in the lung but is also a hallmark of chronic diseases such as asthma. Since IL-13 shares receptors and signalling pathways with IL-4, disentangling the relative contributions of these two type 2 cytokines has been challenging. Additionally, little is known about the singular role of IL-13 in more acute settings of tissue injury/repair and whether IL-13 regulates remodelling of the extracellular matrix following tissue injury. In this study, we used Nippostrongylus brasiliensis infection as model of acute lung tissue damage and repair by comparing responses between WT and IL-13-deficient mice, in which IL-4 signalling is intact.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJames Parkinson
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListmonohydroxylated residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-10-05 22:53:55ID requested
12021-06-10 22:03:05announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Mouse, Lung, IL-13, Helminth, Parasite
Contact List
Prof. Judi Allen
contact affiliationFaculty of Biology Medicine and Health, Wellcome Trust Centre for Cell-Matrix Research, Manchester Centre University of Manchester, United Kingdom
contact emailjudi.allen@manchester.ac.uk
lab head
James Parkinson
contact affiliationUniversity of Manchester
contact emailjames.parkinson@manchester.ac.uk
dataset submitter
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