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PXD021852

PXD021852 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleIdentification of new immunomarkers of active antibody-mediated rejection through glomerular proteome analysis in kidney transplantation
DescriptionIssues remain in the diagnosis of active antibody-mediated rejection (ABMR) in human kidney transplantation, as the hallmark criteria, the microcirculation inflammation scores and the C4d deposits, still lack reproducibility and sensitivity respectively. Using laser microdissection combined with mass spectrometry-based proteomics, this study presents the characterization of active antibody-mediated glomerular injuries, marked by evidences of leukocyte activation and migration, cellular stress through type I and II interferons and of microcirculation remodeling.
HostingRepositoryPRIDE
AnnounceDate2022-05-25
AnnouncementXMLSubmission_2022-05-25_09:09:34.145.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterDupuy Jean-William
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListacetylated residue; monohydroxylated residue; iodoacetamide derivatized residue; deamidated residue
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-10-05 22:51:32ID requested
12022-05-25 09:09:34announced
Publication List
Chauveau B, Raymond AA, Di Tommaso S, Visentin J, Vermorel A, Dugot-Senant N, Dourthe C, Dupuy JW, D, é, chanet-Merville J, Duong Van Huyen JP, Rabant M, Couzi L, Saltel F, Merville P, The Proteome of Antibody-Mediated Rejection: From Glomerulitis to Transplant Glomerulopathy. Biomedicines, 10(3):(2022) [pubmed]
Keyword List
submitter keyword: antibody-mediated rejection, glomerulus, proteomics, mass spectrometry, kidney transplantation, biomarker
Contact List
Pierre Merville
contact affiliationUniv. Bordeaux, CNRS, ImmunoConcEpT, UMR 5164, 146 rue Léo Saignat, F-33000 Bordeaux, France
contact emailpierre.merville@chu-bordeaux.fr
lab head
Dupuy Jean-William
contact affiliationPlateforme Proteome Bordeaux
contact emailjean-william.dupuy@u-bordeaux.fr
dataset submitter
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Dataset FTP location
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