PXD021852 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Identification of new immunomarkers of active antibody-mediated rejection through glomerular proteome analysis in kidney transplantation |
Description | Issues remain in the diagnosis of active antibody-mediated rejection (ABMR) in human kidney transplantation, as the hallmark criteria, the microcirculation inflammation scores and the C4d deposits, still lack reproducibility and sensitivity respectively. Using laser microdissection combined with mass spectrometry-based proteomics, this study presents the characterization of active antibody-mediated glomerular injuries, marked by evidences of leukocyte activation and migration, cellular stress through type I and II interferons and of microcirculation remodeling. |
HostingRepository | PRIDE |
AnnounceDate | 2022-05-25 |
AnnouncementXML | Submission_2022-05-25_09:09:34.145.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Dupuy Jean-William |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue; deamidated residue |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-10-05 22:51:32 | ID requested | |
⏵ 1 | 2022-05-25 09:09:34 | announced | |
Publication List
Chauveau B, Raymond AA, Di Tommaso S, Visentin J, Vermorel A, Dugot-Senant N, Dourthe C, Dupuy JW, D, é, chanet-Merville J, Duong Van Huyen JP, Rabant M, Couzi L, Saltel F, Merville P, The Proteome of Antibody-Mediated Rejection: From Glomerulitis to Transplant Glomerulopathy. Biomedicines, 10(3):(2022) [pubmed] |
Keyword List
submitter keyword: antibody-mediated rejection, glomerulus, proteomics, mass spectrometry, kidney transplantation, biomarker |
Contact List
Pierre Merville |
contact affiliation | Univ. Bordeaux, CNRS, ImmunoConcEpT, UMR 5164, 146 rue Léo Saignat, F-33000 Bordeaux, France |
contact email | pierre.merville@chu-bordeaux.fr |
lab head | |
Dupuy Jean-William |
contact affiliation | Plateforme Proteome Bordeaux |
contact email | jean-william.dupuy@u-bordeaux.fr |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/04/PXD021852 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD021852
- Label: PRIDE project
- Name: Identification of new immunomarkers of active antibody-mediated rejection through glomerular proteome analysis in kidney transplantation