PXD021852

PXD021852 is an original dataset announced via ProteomeXchange.

Title	Identification of new immunomarkers of active antibody-mediated rejection through glomerular proteome analysis in kidney transplantation
Description	Issues remain in the diagnosis of active antibody-mediated rejection (ABMR) in human kidney transplantation, as the hallmark criteria, the microcirculation inflammation scores and the C4d deposits, still lack reproducibility and sensitivity respectively. Using laser microdissection combined with mass spectrometry-based proteomics, this study presents the characterization of active antibody-mediated glomerular injuries, marked by evidences of leukocyte activation and migration, cellular stress through type I and II interferons and of microcirculation remodeling.
HostingRepository	PRIDE
AnnounceDate	2022-05-25
AnnouncementXML	Submission_2022-05-25_09:09:34.145.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Dupuy Jean-William
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue; deamidated residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2020-10-05 22:51:32	ID requested
⏵ 1	2022-05-25 09:09:34	announced

Chauveau B, Raymond AA, Di Tommaso S, Visentin J, Vermorel A, Dugot-Senant N, Dourthe C, Dupuy JW, D, é, chanet-Merville J, Duong Van Huyen JP, Rabant M, Couzi L, Saltel F, Merville P, The Proteome of Antibody-Mediated Rejection: From Glomerulitis to Transplant Glomerulopathy. Biomedicines, 10(3):(2022) [pubmed]

submitter keyword: antibody-mediated rejection, glomerulus, proteomics, mass spectrometry, kidney transplantation, biomarker

Pierre Merville
contact affiliation	Univ. Bordeaux, CNRS, ImmunoConcEpT, UMR 5164, 146 rue Léo Saignat, F-33000 Bordeaux, France
contact email	pierre.merville@chu-bordeaux.fr
lab head
Dupuy Jean-William
contact affiliation	Plateforme Proteome Bordeaux
contact email	jean-william.dupuy@u-bordeaux.fr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/04/PXD021852

PRIDE project URI

• PRIDE
  1. PXD021852
     1. Label: PRIDE project
     2. Name: Identification of new immunomarkers of active antibody-mediated rejection through glomerular proteome analysis in kidney transplantation