PXD021795

PXD021795 is an original dataset announced via ProteomeXchange.

Title	E-cadherin: Unexpected actor of invadopodia formation in pancreatic cancer
Description	E-cadherin is known as an epithelial marker often associated with tumour suppressive function. However, several studies revealed that some tumours cells, such as pancreatic cancer cells, with epithelial traits and high E-cadherin expression can undergo metastasis and form secondary tumours. These observations suggest an important role of E-cadherin in early stages of tumour cells invasion. Pancreatic ductal adenocarcinoma (PDAC) are highly metastatic with poor prognosis cancer and therefore provide an useful model to clarify E-cadherin function on tumour progression. To address the molecular function of E-cadherin regarding PDAC aggressivity, we knock-down E-cadherin expression in a pancreatic cancer cell line and analysed the consequences of E-cadherin depletion on the capacity of cells to form invasive structures called invadopodia. We then deciphered the molecular mechanisms by which E-cadherin regulates invadopodia formation by performing analysis of proteomes from control and E-cadh depleted cells.
HostingRepository	PRIDE
AnnounceDate	2025-05-14
AnnouncementXML	Submission_2025-05-14_07:56:16.625.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	AUDEBERT Stephane
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2020-10-02 04:17:35	ID requested
⏵ 1	2025-05-14 07:56:17	announced

Dataset with its publication pending

submitter keyword: Human, LC-MSMS, E-cadherin , cell invasion, invadopodia, pancreatic cancer

Audebert Stephane / Camoin Luc
contact affiliation	Marseille Proteomic, Centre de Recherche en Cancérologie de Marseille, CRCM Inserm UMR1068, CNRS UMR7258, Aix Marseille Université U105, Institut Paoli Calmettes 27 Boulevard Leï Roure CS30059 13273 Marseille Cedex 09 France
contact email	stephane.Audebert@inserm.fr
lab head
AUDEBERT Stephane
contact affiliation	Marseille Proteomic, Centre de Recherche en Cancérologie de Marseille, Inserm UMR1068, CNRS UMR7258, Aix Marseille Université U105, Institut Paoli Calmettes, 27 Boulevard Leï Roure CS30059 13273 Marseille Cedex 09 France
contact email	stephane.audebert@inserm.fr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD021795

PRIDE project URI

• PRIDE
  1. PXD021795
     1. Label: PRIDE project
     2. Name: E-cadherin: Unexpected actor of invadopodia formation in pancreatic cancer