PXD021785

PXD021785 is an original dataset announced via ProteomeXchange.

Title	Enhancing the chondrogenic potential of chondrogenic progenitor cells by deletion of RAB5C
Description	Osteoarthritis (OA) is the most prevalent chronic joint disease that affects a majority of the elderly. Chondrogenic progenitor cells (CPCs) reside in late stage OA cartilage tissue, producing a fibrocartilagenous extra-cellular matrix and can be manipulated in-vitro, to deposit proteins of healthy articular cartilage. CPCs are under control of SOX9 and RUNX2 and in order to enhance their chondrogenic potential, we found that RUNX2 plays a pivotal role in chondrogenesis. In another approach, CPCs carrying a knockout of RAB5C, a protein involved in endosomal trafficking, demonstrated elevated expression of various chondrogenic markers including the SOX trio and displayed an increased COL2 deposition, whereas no changes of COL1 deposition was observed. We report RAB5C as an attractive target for future therapeutic approaches to increase the COL2 content in the diseased joint.
HostingRepository	PRIDE
AnnounceDate	2022-02-16
AnnouncementXML	Submission_2022-02-16_08:15:40.724.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Christof Lenz
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	TripleTOF 5600; Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2020-10-02 00:50:55	ID requested
⏵ 1	2022-02-16 08:15:41	announced

Janssen JN, Izzi V, Henze E, Cing, ö, z G, Lowen F, K, ü, ttner D, Neumann R, Lenz C, Rosen V, Miosge N, Enhancing the chondrogenic potential of chondrogenic progenitor cells by deleting RAB5C. iScience, 24(5):102464(2021) [pubmed]

submitter keyword: chondrogenic progenitor cells

RAB5C

osteoarthritis

Christof Lenz
contact affiliation	University Medical Center Goettingen, Institute of Clinical Chemistry
contact email	christof.lenz@med.uni-goettingen.de
lab head
Christof Lenz
contact affiliation	Max Planck Institute for Biophysical Chemistry
contact email	christof.lenz@mpibpc.mpg.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/09/PXD021785

PRIDE project URI

• PRIDE
  1. PXD021785
     1. Label: PRIDE project
     2. Name: Enhancing the chondrogenic potential of chondrogenic progenitor cells by deletion of RAB5C