PXD021749

PXD021749 is an original dataset announced via ProteomeXchange.

Title	Schlafen 5 as a Novel Therapeutic Target in Pancreatic Ductal Adenocarcinoma
Description	We provide evidence that a member of the human Schlafen (SLFN) family of proteins, SLFN5, is overexpressed in human pancreatic ductal adenocarcinoma (PDAC). Targeted deletion of SLFN5 results in decreased PDAC cell proliferation and suppresses PDAC tumorigenesis in in vivo PDAC models. Importantly, high expression levels of SLFN5 correlate with worse outcomes in PDAC patients, implicating SLFN5 in the pathophysiology of PDAC that leads to poor outcomes. Our studies establish novel regulatory effects of SLFN5 on cell cycle progression through binding/blocking of the transcriptional repressor E2F7, promoting transcription of key genes that stimulate S phase progression. Together, our studies suggest an essential role for SLFN5 in PDAC and support the potential for developing new therapeutic approaches for the treatment of pancreatic cancer through SLFN5 targeting.
HostingRepository	PRIDE
AnnounceDate	2021-04-14
AnnouncementXML	Submission_2021-04-14_09:39:20.775.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD021749
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Paul Thomas
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue; deamidated residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2020-09-30 00:02:29	ID requested
⏵ 1	2021-04-14 09:39:21	announced

Fischietti M, Eckerdt F, Blyth GT, Arslan AD, Mati WM, Oku CV, Perez RE, Lee-Chang C, Kosciuczuk EM, Saleiro D, Beauchamp EM, Lesniak MS, Verzella D, Sun L, Fish EN, Yang GY, Qiang W, Platanias LC, Schlafen 5 as a novel therapeutic target in pancreatic ductal adenocarcinoma. Oncogene, 40(18):3273-3286(2021) [pubmed]

submitter keyword: Schlafen 5, Pancreatic Ductal Adenocarcinoma

Leonidas C. Platanias
contact affiliation	Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL, 60611, USA Division of Hematology-Oncology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA
contact email	l-platanias@northwestern.edu
lab head
Paul Thomas
contact affiliation	Northwestern University
contact email	paul-thomas@northwestern.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/04/PXD021749

PRIDE project URI

• PRIDE
  1. PXD021749
     1. Label: PRIDE project
     2. Name: Schlafen 5 as a Novel Therapeutic Target in Pancreatic Ductal Adenocarcinoma