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PXD021733

PXD021733 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleVWCE inhibited the proliferation, migration, invasion, and chemoresistance of the breast cancer cell lines
DescriptionBreast cancer remains a leading cause of cancer-related death, for which the majority of deaths result from metastases. Von Willebrand factor C and EGF domain (VWCE) is a member of the Von Willebrand factor (VWF) gene family; however, its function, regulatory mechanism, and clinical value in breast cancer remain unclear. In the present study, we sought to elucidate the role of VWCE in breast cancer metastasis. We examined the expression of VWCE in breast cancer tissues and normal control tissues of 50 breast cancer patients. We found that VWCE expression was downregulated in breast cancer cells and tissues compared to normal breast epithelial cells or the adjacent normal tissues. To explore the role of VWCE in human breast cancer development, we introduced a VWCE-overexpressing or control lentiviral vector into the breast cancer MDA-MB-453 and MDA-MB-231 lines in vitro. The overexpression of VWCE inhibited the proliferation, migration, invasion, and chemoresistance of the breast cancer cell lines. More import
HostingRepositoryiProX
AnnounceDate2020-09-29
AnnouncementXMLSubmission_2020-10-20_18:35:44.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterDan Zhang
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-09-29 00:55:20ID requested
12020-10-20 18:35:44announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: breast cancer cells, VWCE,tumor suppressor,WDR1,metastasis
Contact List
Ni Xie
contact affiliationThe First Affiliated Hospital of Shenzhen University,Health Science Center
contact emailxn100@szu.edu.cn
lab head
Dan Zhang
contact affiliationShenzhen Second People’s Hospital
contact email13762470784@163.com
dataset submitter
Full Dataset Link List
iProX dataset URI