PXD021700

PXD021700 is an original dataset announced via ProteomeXchange.

Title	Histone PTMs dataset for Hyposuccinylation Derived from Abnormal Metabolism Promotes the Cell Migration of Esophageal Squamous Cell Cancer
Description	We identify abnormal protein and post-translational modification (PTM) pathways, including many downregulated lysine succinylation sites in cancer cells. Focusing on hyposuccinylation, we reveal that this altered PTM was enriched on enzymes of metabolic pathways and the reduced succinyl-CoA may lead to this phenomenon.
HostingRepository	iProX
AnnounceDate	2020-09-26
AnnouncementXML	Submission_2023-03-01_23:11:54.846.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Zhenchang Guo
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	acetylated residue; methylthiolated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2020-09-27 20:20:57	ID requested
1	2020-09-27 20:41:56	announced
⏵ 2	2023-03-01 23:11:56	announced	2023-03-02: Update publication information.

Guo Z, Pan F, Peng L, Tian S, Jiao J, Liao L, Lu C, Zhai G, Wu Z, Dong H, Xu X, Wu J, Chen P, Bai X, Lin D, Xu L, Li E, Zhang K, Systematic Proteome and Lysine Succinylome Analysis Reveals Enhanced Cell Migration by Hyposuccinylation in Esophageal Squamous Cell Carcinoma. Mol Cell Proteomics, 20():100053(2021) [pubmed]

submitter keyword: Lysine succinylation, acetylation, phosphorylation, ESCC, proteomics, histone PTMs

Kai Zhang
contact affiliation	Department of Biochemistry and Molecular Biology, Tianjin Medical University
contact email	kzhang@tmu.edu.cn
lab head
Zhenchang Guo
contact affiliation	Tianjin Medical University
contact email	guozhenchang@tmu.edu.cn
dataset submitter

iProX dataset URI