PXD021691

PXD021691 is an original dataset announced via ProteomeXchange.

Title	Proximity labeling of Siglec-1 counter-receptors on activated regulatory T cells using Siglec-1-HRP multimers on nano-beads
Description	Siglec-1 is a macrophage lectin-like receptor that mediates sialic acid-dependent cellular interactions. It was shown previously to promote inflammation in autoimmune disease through suppressing the expansion of regulatory T cells (Tregs). We have investigated the molecular basis for Siglec-1 binding to these cells using in vitro-induced Tregs. A proximity labelling and proteomics strategy were used to identify glycoproteins expressed by activated Tregs that may function as Siglec-1 counter-receptors.
HostingRepository	PRIDE
AnnounceDate	2021-04-28
AnnouncementXML	Submission_2021-04-28_04:57:28.466.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Gang Wu
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Homo sapiens (Human); NCBI TaxID: 9606; scientific name: Armoracia rusticana; NCBI TaxID: 3704;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue; deamidated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2020-09-25 06:45:46	ID requested
⏵ 1	2021-04-28 04:57:28	announced

Dataset with its publication pending

submitter keyword: Siglec-1, counter-receptor, proximity labeling

Paul R. Crocker
contact affiliation	Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, Scotland, United Kingdom
contact email	p.r.crocker@dundee.ac.uk
lab head
Gang Wu
contact affiliation	Imperial College London
contact email	g.wu10@imperial.ac.uk
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD021691
     1. Label: PRIDE project
     2. Name: Proximity labeling of Siglec-1 counter-receptors on activated regulatory T cells using Siglec-1-HRP multimers on nano-beads