PXD021688

PXD021688 is an original dataset announced via ProteomeXchange.

Title	Licorice Ameliorates Cisplatin-Induced Hepatotoxicity through Anti-apoptosis, Anti-oxidative Stress, Anti-inflammation, and Acceleration of Metabolism
Description	Cisplatin (CP) is one of the most effective antitumor drugs in the clinic, but has serious adverse reactions, and its hepatotoxicity has not been fully investigated. Licorice (GC), a traditional herbal medicine, has been commonly used as a detoxifier for poisons and drugs, and may be an effective drug for CP-induced hepatotoxicity. However, its mechanism and the effector molecules remain ambiguous. Therefore, in this study, a network pharmacology and proteomics-based approach was established, and a panoramic view of the detoxification of GC on CP-induced hepatotoxicity was provided. The experimental results indicated that GC can recover functional indices and pathological liver injury, inhibit hepatocyte apoptosis, upregulate B-cell lymphoma/leukemia 2 (Bcl-2) and superoxide dismutase (SOD) levels, and downregulate cellular tumor antigen p53 (p53), caspase-3, malondialdehyde (MDA), high mobility group protein B1 (HMGB1), tumor necrosis factor alpha (TNF-α), and interleukin 1β (IL-1β) levels. Proteomics indicated that GC regulates phosphatidylcholine translocator ABCB1 (ABCB1B), canalicular multispecific organic anion transporter 1 (ABCC2), cytochrome P450 4A2 (CYP4A2), cytochrome P450 1A1 (CYP1A1), cytochrome P450 1A2 (CYP1A2), estrogen receptor (ESR1), and DNA topoisomerase 2-alpha (TOP2A), inhibits oxidative stress, apoptosis, and inflammatory responses, and accelerates drug metabolism. In this study, we provide the investigation of the efficacy of GC against CP-induced hepatotoxicity, and offers a promising alternative for the clinic.
HostingRepository	PRIDE
AnnounceDate	2020-11-27
AnnouncementXML	Submission_2020-11-27_07:48:20.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Man Qiong
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	No PTMs are included in the dataset
Instrument	autoflex

Revision	Datetime	Status	ChangeLog Entry
0	2020-09-25 06:45:28	ID requested
⏵ 1	2020-11-27 07:48:21	announced

Man Q, Deng Y, Li P, Ma J, Yang Z, Yang X, Zhou Y, Yan X, Licorice Ameliorates Cisplatin-Induced Hepatotoxicity Through Antiapoptosis, Antioxidative Stress, Anti-Inflammation, and Acceleration of Metabolism. Front Pharmacol, 11():563750(2020) [pubmed]

submitter keyword: cisplatin, detoxification, hepatotoxicity, licorice, proteomics

Yi Deng
contact affiliation	College of Pharmacy, Gansu University of Chinese Medicine, Lanzhou, China
contact email	dengyi_gszy@163.com
lab head
Man Qiong
contact affiliation	College of Pharmacy, Gansu University of Chinese Medicine
contact email	gretam@163.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/11/PXD021688

PRIDE project URI

• PRIDE
  1. PXD021688
     1. Label: PRIDE project
     2. Name: Licorice Ameliorates Cisplatin-Induced Hepatotoxicity through Anti-apoptosis, Anti-oxidative Stress, Anti-inflammation, and Acceleration of Metabolism