PXD021582 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | TMT-coupled phosphoproteomics support novel role of TWEAK/Fn14 signaling in synaptic function |
Description | The study aims at illustrate novel role of TWEAK/Fn14 signaling in synapse function by combining electrophysiological and phosphoproteomic approaches. The results show that TWEAK acutely dampens basal synaptic transmission and plasticity through neuronal Fn14 and impacts the phosphorylation state of pre- and post-synaptic proteins in adult mouse hippocampal slices. Two models featuring synaptic deficits were used in the study. Blocking TWEAK/Fn14 signaling augments synaptic function in hippocampal slices from amyloid beta-overexpressing mice. After stroke, genetic or pharmacological inhibition of TWEAK/Fn14 signaling augments basal synaptic transmission and normalizes plasticity. Our data support a glial/neuronal axis that critically modifies synaptic physiology and pathophysiology in different contexts in the mature brain and may be a therapeutic target for improving neurophysiological outcomes. |
HostingRepository | PRIDE |
AnnounceDate | 2021-02-02 |
AnnouncementXML | Submission_2021-02-01_23:16:53.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Ru Wei |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | iodoacetamide derivatized residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-09-21 00:08:38 | ID requested | |
⏵ 1 | 2021-02-01 23:16:54 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: synaptic transmission, synaptic plasticity, neurodegeneration, stroke, TWEAK, Fn14, phosphoproteomics |
Contact List
Doug Johnson |
contact affiliation | Chemical Biology & Proteomics, Biogen |
contact email | doug.johnson2@biogen.com |
lab head | |
Ru Wei |
contact affiliation | Biogen |
contact email | ru.wei@biogen.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/02/PXD021582 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD021582
- Label: PRIDE project
- Name: TMT-coupled phosphoproteomics support novel role of TWEAK/Fn14 signaling in synaptic function