<<< Full experiment listing

PXD021582

PXD021582 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleTMT-coupled phosphoproteomics support novel role of TWEAK/Fn14 signaling in synaptic function
DescriptionThe study aims at illustrate novel role of TWEAK/Fn14 signaling in synapse function by combining electrophysiological and phosphoproteomic approaches. The results show that TWEAK acutely dampens basal synaptic transmission and plasticity through neuronal Fn14 and impacts the phosphorylation state of pre- and post-synaptic proteins in adult mouse hippocampal slices. Two models featuring synaptic deficits were used in the study. Blocking TWEAK/Fn14 signaling augments synaptic function in hippocampal slices from amyloid beta-overexpressing mice. After stroke, genetic or pharmacological inhibition of TWEAK/Fn14 signaling augments basal synaptic transmission and normalizes plasticity. Our data support a glial/neuronal axis that critically modifies synaptic physiology and pathophysiology in different contexts in the mature brain and may be a therapeutic target for improving neurophysiological outcomes.
HostingRepositoryPRIDE
AnnounceDate2021-02-02
AnnouncementXMLSubmission_2021-02-01_23:16:53.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterRu Wei
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListiodoacetamide derivatized residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-09-21 00:08:38ID requested
12021-02-01 23:16:54announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: synaptic transmission, synaptic plasticity, neurodegeneration, stroke, TWEAK, Fn14, phosphoproteomics
Contact List
Doug Johnson
contact affiliationChemical Biology & Proteomics, Biogen
contact emaildoug.johnson2@biogen.com
lab head
Ru Wei
contact affiliationBiogen
contact emailru.wei@biogen.com
dataset submitter
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/02/PXD021582
PRIDE project URI
Repository Record List
[ + ]