PXD021567

PXD021567 is an original dataset announced via ProteomeXchange.

Title	Proteome-wide Hyposuccinylation of Esophageal Squamous Cell Cancer to Promotion of Tumor Metabolism and Migration
Description	We identify abnormal protein and post-translational modification (PTM) pathways, including significantly downregulated lysine succinylation sites in cancer cells. Focusing on hyposuccinylation, we reveal that this altered PTM was enriched on enzymes of metabolic pathways inextricably linked with cancer metabolism. Importantly, ESCC malignant behaviors such as cell migration are inhibited once the level of succinylation was restored in vitro or in vivo. This effect was further verified by mutations to disrupt succinylation sites in candidate proteins.
HostingRepository	iProX
AnnounceDate	2020-09-18
AnnouncementXML	Submission_2023-03-02_18:36:38.847.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Zhenchang Guo
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	6x(13)C labeled L-lysine; acetylated residue; phosphorylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2020-09-18 07:44:40	ID requested
1	2020-09-18 07:53:31	announced
⏵ 2	2023-03-02 18:36:39	announced	2023-03-03: Update publication information.

Guo Z, Pan F, Peng L, Tian S, Jiao J, Liao L, Lu C, Zhai G, Wu Z, Dong H, Xu X, Wu J, Chen P, Bai X, Lin D, Xu L, Li E, Zhang K, Systematic Proteome and Lysine Succinylome Analysis Reveals Enhanced Cell Migration by Hyposuccinylation in Esophageal Squamous Cell Carcinoma. Mol Cell Proteomics, 20():100053(2021) [pubmed]

submitter keyword: Esophageal squamous, Post-translational modification, Succinylation, Migration

Kai Zhang
contact affiliation	Tianjin Medical University
contact email	Kzhang@tmu.edu.cn
lab head
Zhenchang Guo
contact affiliation	Tianjin Medical University
contact email	guozhenchang@tmu.edu.cn
dataset submitter

iProX dataset URI