PXD021492

PXD021492 is an original dataset announced via ProteomeXchange.

Title	Characterisation of the adhesome of patient-derived cutaneous squamous carcinoma cells
Description	Interactions between cells and the extracellular matrix, mediated by integrin adhesion complexes (IACs), play key roles in cancer progression and metastasis. We report here systems-level changes in the adhesome during progression of a patient-derived cutaneous squamous cell carcinoma (cSCC). We found that the actin regulatory protein Mena is enriched in IACs in metastatic cSCC cells and is connected within a subnetwork of actin-binding proteins to the LINC complex component nesprin-2.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:44:25.073.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Adam Byron
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2020-09-15 09:30:44	ID requested
1	2023-03-25 14:04:30	announced
⏵ 2	2023-11-14 08:44:26	announced	2023-11-14: Updated project metadata.

Li Mow Chee F, Beernaert B, Griffith BGC, Loftus AEP, Kumar Y, Wills JC, Lee M, Valli J, Wheeler AP, Armstrong JD, Parsons M, Leigh IM, Proby CM, von Kriegsheim A, Bickmore WA, Frame MC, Byron A, Mena regulates nesprin-2 to control actin-nuclear lamina associations, trans-nuclear membrane signalling and gene expression. Nat Commun, 14(1):1602(2023) [pubmed]

submitter keyword: cancer, adhesome, adhesion,human

Margaret Frame
contact affiliation	University of Edinburgh
contact email	m.frame@ed.ac.uk
lab head
Adam Byron
contact affiliation	University of Manchester
contact email	adam.byron@igmm.ed.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD021492

PRIDE project URI

• PRIDE
  1. PXD021492
     1. Label: PRIDE project
     2. Name: Characterisation of the adhesome of patient-derived cutaneous squamous carcinoma cells