PXD021473

PXD021473 is an original dataset announced via ProteomeXchange.

Title	Activity-Dependent Mitochondrial Plasticity and Mitoproteome are Dysregulated in Fragile X Syndrome
Description	We measure changes in the proteome after 48 hours of activity deprivation with tetrodotoxin (TTX) and the NMDA receptor antagonist (2R)-amino-5-phosphonovaleric acid (APV). We used wild type and FMRP mutant primary cortical neurons treated with vehicle or treated with TTX-APV.
HostingRepository	PRIDE
AnnounceDate	2022-02-16
AnnouncementXML	Submission_2022-02-16_08:02:33.611.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD021473
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Victor Faundez
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2020-09-14 08:12:28	ID requested
⏵ 1	2022-02-16 08:02:34	announced

B, ü, low P, Zlatic SA, Wenner PA, Bassell GJ, Faundez V, FMRP attenuates activity dependent modifications in the mitochondrial proteome. Mol Brain, 14(1):75(2021) [pubmed]

submitter keyword: Autism, FMR1, Fmrp, Mitochondria, homeostatic plasticity, mitoproteome, Fragile X syndrome

Victor Faundez
contact affiliation	Professor, Dept. Cell Biology, Emory University
contact email	vfaunde@emory.edu
lab head
Victor Faundez
contact affiliation	Emory University
contact email	vfaunde@emory.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/09/PXD021473

PRIDE project URI

• PRIDE
  1. PXD021473
     1. Label: PRIDE project
     2. Name: Activity-Dependent Mitochondrial Plasticity and Mitoproteome are Dysregulated in Fragile X Syndrome