PXD021433

PXD021433 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Uncovering molecular targets for regenerative therapy in degenerative disc disease: do small Leucine-Rich proteoglycans hold the key?
Description	Small leucine-rich proteoglycans (SLRPs) play an essential role in extracellular matrix (ECM) organization and function. Recently, dysregulation of SLRPs has been implicated in degenerative disc disease (DDD). An in-depth analysis using high-throughput proteomic sequencing might provide valuable information on their implications in health and disease. Hence we utilized proteomics for analysing the expression of SLRPs in fetal, healthy adult, and degenerated discs to identify possible molecular targets to halt or reverse the degenerative process.
HostingRepository	PRIDE
AnnounceDate	2025-01-08
AnnouncementXML	Submission_2025-01-07_18:26:39.046.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD021433
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Chitraa Tangavel
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	S-carboxamidoethyl-L-cysteine; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Velos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2020-09-11 03:00:52	ID requested
⏵ 1	2025-01-07 18:26:39	announced

Publication List

10.1016/J.SPINEE.2020.04.011;
10.6019/PXD021433;

10.1016/J.SPINEE.2020.04.011;

10.6019/PXD021433;

Keyword List

submitter keyword: Human, NP, Regenerative therapy, intervertebral disc, SLRP

submitter keyword: Human, NP, Regenerative therapy, intervertebral disc, SLRP

Contact List

Dr Chitraa Tangavel
contact affiliation	Research Scientist, Ganga Orthopedic Research and Education Foundation, 187, Mettupalayam Road, Kavundampalayam, Coimbatore- 641030, Tamil Nadu, India
contact email	cthangavel@gmail.com
lab head
Chitraa Tangavel
contact affiliation	Research Scientist, Ganga Orthopedic Research and Education Foundation, 187, Mettupalayam Road, Kavundampalayam, Coimbatore- 641030, Tamil Nadu, India
contact email	cthangavel@gmail.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/01/PXD021433
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/01/PXD021433

PRIDE project URI

Repository Record List

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