PXD021429

PXD021429 is an original dataset announced via ProteomeXchange.

Title	LSD1 interactome in Glioblastoma
Description	Tumor-initiating cells (TICs) play a critical role in glioblastoma (GBM) maintenance being responsible for its heterogeneity and resistance to standard therapy. A step toward clinical translation includes GBM TIC targeting. Among the molecules tested for GBM treatment, are those targeting epigenetic modifiers. By using patient-derived TICs and xenograft orthotopic models, we identified Lysine-specific histone demethylase 1A (LSD1) as a potentially druggable target in GBM. LSD1-directed therapy by means of the selective, orally bioavailable and brain penetrant inhibitor DDP_38003 effectively impairs growth, stem-like features and tumorigenic potential of GBM TICs. Our findings point to LSD1 as a positive regulator of Activating Transcription Factor 4 (ATF4)-dependent response in all stress conditions arising during tumor growth and therapy. Thus, through the downregulation of either ATF4 and its adaptive genes, LSD1 targeting is likely a promising strategy to hit GBM TICs by counteracting the ATF4-mediated adaptation to stress.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:51:22.549.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Enrico Massignani
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2020-09-11 01:00:24	ID requested
1	2022-06-02 09:04:52	announced
⏵ 2	2023-11-14 08:51:22	announced	2023-11-14: Updated project metadata.

Dataset with its publication pending

submitter keyword: glioblastoma,LSD1, protein complex, LSD1 inhibitor, targeted therapy

Tiziana Bonaldi
contact affiliation	Department of Experimental Oncology, European Institute of Oncology (IEO), IRCCS, Milan 20139, Italy
contact email	tiziana.bonaldi@ieo.it
lab head
Enrico Massignani
contact affiliation	European Institute of Oncology IRCSS, Department of Experimental Oncology, Milan, Italy
contact email	enrico.massignani@ieo.it
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/06/PXD021429

PRIDE project URI

• PRIDE
  1. PXD021429
     1. Label: PRIDE project
     2. Name: LSD1 interactome in Glioblastoma