PXD021261

PXD021261 is an original dataset announced via ProteomeXchange.

Title	Mass spectrometry-based redox and protein profiling reveals distinct protein expression and oxidation patterns in failing human hearts
Description	Oxidative stress plays a key role in development and progression of cardiovascular diseases and it is correlated with left ventricular dysfunction and heart failure (HF). Oxidative environments lead to the formation of intra- and intermolecular disulfide bonds, as well as to plethora of other reversible and irreversible oxidative amino acid modifications, affecting the functionality of the proteins. Here we report that heart failure due to ischemic cardiomyopathy (ICM) or dilated cardiomyopathy (DCM) is correlated with increase in oxidative stress compared to non-failing control hearts, manifested through decreased GSH/GSSG ratio in failing heart tissue samples and adaptations of cardiac redox proteome which occur in correlation with two different heart pathologies.
HostingRepository	PRIDE
AnnounceDate	2021-09-09
AnnouncementXML	Submission_2021-09-09_08:50:32.813.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Tamara Tomin
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	L-methionine sulfone; N-ethylmaleimide derivatized cysteine; (2)H deuterium tagged reagent
Instrument	maXis

Revision	Datetime	Status	ChangeLog Entry
0	2020-09-02 00:35:32	ID requested
⏵ 1	2021-09-09 08:50:33	announced

Tomin T, Schittmayer M, Sedej S, Bugger H, Gollmer J, Honeder S, Darnhofer B, Liesinger L, Zuckermann A, Rainer PP, Birner-Gruenberger R, Mass Spectrometry-Based Redox and Protein Profiling of Failing Human Hearts. Int J Mol Sci, 22(4):(2021) [pubmed]

submitter keyword: redox proteomics, heart failure, oxidative stress, myofibrilar proteins, ischemic cardiomyopathy, dilated cardiomyopathy

Ruth Birner-Gruenberger
contact affiliation	Full Professor for Analytical Chemistry Institute of Chemical Technologies and Analytics TU Wien Getreidemarkt 9/E164 A-1060 Vienna Austria
contact email	ruth.birner-gruenberger@tuwien.ac.at
lab head
Tamara Tomin
contact affiliation	Senior Scientist at Institute of Chemical Technologies and Analytics Faculty of Technical Chemistry, TU Wien Getreidemarkt 9/164, 1060 Vienna
contact email	tamara.tomin@tuwien.ac.at
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/09/PXD021261

PRIDE project URI

• PRIDE
  1. PXD021261
     1. Label: PRIDE project
     2. Name: Mass spectrometry-based redox and protein profiling reveals distinct protein expression and oxidation patterns in failing human hearts