PXD021250

PXD021250 is an original dataset announced via ProteomeXchange.

Title	A proteomic map of resting and activated CD4+ T cells
Description	CD4+ T cells (T helper cells) are cytokine-producing adaptive immune cells that activate or regulate the responses of different immune cells. They are known to play crucial roles in antibody class switching in B cells, neutrophil recruitment and activation of macrophages and CD8+ cytotoxic T cells. The activation and functional status of CD4+ T cells is important for adequate responses to pathogen infections but has also been associated with auto-immune disorders and survival in several cancers. In the current study, we carried out proteomic profiling of resting and activated primary human CD4+ T cells from healthy donors. In addition to identifying known markers of CD4+ T cell activation, we also identified protein kinases, protein phosphatases, and cytokines to be differentially expressed.
HostingRepository	PRIDE
AnnounceDate	2023-01-18
AnnouncementXML	Submission_2023-01-18_13:39:58.668.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Richard K.Kandasamy
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2020-09-01 04:15:21	ID requested
⏵ 1	2023-01-18 13:39:59	announced

Subbannayya Y, Haug M, Pinto SM, Mohanty V, Me, å, s HZ, Flo TH, Prasad TSK, Kandasamy RK, The Proteomic Landscape of Resting and Activated CD4+ T Cells Reveal Insights into Cell Differentiation and Function. Int J Mol Sci, 22(1):(2020) [pubmed]

submitter keyword: mass spectrometry, CD4+ T helper cells, T lymphocytes, label-free quantitation, systems biology,adaptive immunity

Richard K.Kandasamy
contact affiliation	Systems Inflammation group, Centre of Molecular Inflammation Research (CEMIR), and Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology, Norway
contact email	richard.k.kandasamy@ntnu.no
lab head
Richard K.Kandasamy
contact affiliation	NTNU
contact email	richard.k.kandasamy@ntnu.no
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/01/PXD021250

PRIDE project URI

• PRIDE
  1. PXD021250
     1. Label: PRIDE project
     2. Name: A proteomic map of resting and activated CD4+ T cells